A highly soluble Sleeping Beauty transposase improves control of gene insertion

The Sleeping Beauty (SB) transposon system is an efficient non-viral gene transfer tool in mammalian cells but its broad use has been hampered by uncontrolled transposase gene activity from DNA vectors, posing a risk for genome instability, and by the inability to use transposase protein directly. H...

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Detalles Bibliográficos
Autores principales: Querques, Irma, Mades, Andreas, Zuliani, Cecilia, Miskey, Csaba, Alb, Miriam, Grueso, Esther, Machwirth, Markus, Rausch, Tobias, Einsele, Hermann, Ivics, Zoltán, Hudecek, Michael, Barabas, Orsolya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894935/
https://www.ncbi.nlm.nih.gov/pubmed/31685959
http://dx.doi.org/10.1038/s41587-019-0291-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6894935/
https://www.ncbi.nlm.nih.gov/pubmed/31685959
http://dx.doi.org/10.1038/s41587-019-0291-z

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