Chaotic Dynamics Enhance the Sensitivity of Inner Ear Hair Cells
Hair cells of the auditory and vestibular systems are capable of detecting sounds that induce sub-nanometer vibrations of the hair bundle, below the stochastic noise levels of the surrounding fluid. Furthermore, the auditory system exhibits a highly rapid response time, in the sub-millisecond regime...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895040/ https://www.ncbi.nlm.nih.gov/pubmed/31804578 http://dx.doi.org/10.1038/s41598-019-54952-y |
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author | Faber, Justin Bozovic, Dolores |
author_facet | Faber, Justin Bozovic, Dolores |
author_sort | Faber, Justin |
collection | PubMed |
description | Hair cells of the auditory and vestibular systems are capable of detecting sounds that induce sub-nanometer vibrations of the hair bundle, below the stochastic noise levels of the surrounding fluid. Furthermore, the auditory system exhibits a highly rapid response time, in the sub-millisecond regime. We propose that chaotic dynamics enhance the sensitivity and temporal resolution of the hair bundle response, and we provide experimental and theoretical evidence for this effect. We use the Kolmogorov entropy to measure the degree of chaos in the system and the transfer entropy to quantify the amount of stimulus information captured by the detector. By varying the viscosity and ionic composition of the surrounding fluid, we are able to experimentally modulate the degree of chaos observed in the hair bundle dynamics in vitro. We consistently find that the hair bundle is most sensitive to a stimulus of small amplitude when it is poised in the weakly chaotic regime. Further, we show that the response time to a force step decreases with increasing levels of chaos. These results agree well with our numerical simulations of a chaotic Hopf oscillator and suggest that chaos may be responsible for the high sensitivity and rapid temporal response of hair cells. |
format | Online Article Text |
id | pubmed-6895040 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-68950402019-12-11 Chaotic Dynamics Enhance the Sensitivity of Inner Ear Hair Cells Faber, Justin Bozovic, Dolores Sci Rep Article Hair cells of the auditory and vestibular systems are capable of detecting sounds that induce sub-nanometer vibrations of the hair bundle, below the stochastic noise levels of the surrounding fluid. Furthermore, the auditory system exhibits a highly rapid response time, in the sub-millisecond regime. We propose that chaotic dynamics enhance the sensitivity and temporal resolution of the hair bundle response, and we provide experimental and theoretical evidence for this effect. We use the Kolmogorov entropy to measure the degree of chaos in the system and the transfer entropy to quantify the amount of stimulus information captured by the detector. By varying the viscosity and ionic composition of the surrounding fluid, we are able to experimentally modulate the degree of chaos observed in the hair bundle dynamics in vitro. We consistently find that the hair bundle is most sensitive to a stimulus of small amplitude when it is poised in the weakly chaotic regime. Further, we show that the response time to a force step decreases with increasing levels of chaos. These results agree well with our numerical simulations of a chaotic Hopf oscillator and suggest that chaos may be responsible for the high sensitivity and rapid temporal response of hair cells. Nature Publishing Group UK 2019-12-05 /pmc/articles/PMC6895040/ /pubmed/31804578 http://dx.doi.org/10.1038/s41598-019-54952-y Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Faber, Justin Bozovic, Dolores Chaotic Dynamics Enhance the Sensitivity of Inner Ear Hair Cells |
title | Chaotic Dynamics Enhance the Sensitivity of Inner Ear Hair Cells |
title_full | Chaotic Dynamics Enhance the Sensitivity of Inner Ear Hair Cells |
title_fullStr | Chaotic Dynamics Enhance the Sensitivity of Inner Ear Hair Cells |
title_full_unstemmed | Chaotic Dynamics Enhance the Sensitivity of Inner Ear Hair Cells |
title_short | Chaotic Dynamics Enhance the Sensitivity of Inner Ear Hair Cells |
title_sort | chaotic dynamics enhance the sensitivity of inner ear hair cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895040/ https://www.ncbi.nlm.nih.gov/pubmed/31804578 http://dx.doi.org/10.1038/s41598-019-54952-y |
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