Aurora-A mediated phosphorylation of LDHB promotes glycolysis and tumor progression by relieving the substrate-inhibition effect

Overexpressed Aurora-A kinase promotes tumor growth through various pathways, but whether Aurora-A is also involved in metabolic reprogramming-mediated cancer progression remains unknown. Here, we report that Aurora-A directly interacts with and phosphorylates lactate dehydrogenase B (LDHB), a subun...

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Detalles Bibliográficos
Autores principales: Cheng, Aoxing, Zhang, Peng, Wang, Bo, Yang, Dongdong, Duan, Xiaotao, Jiang, Yongliang, Xu, Tian, Jiang, Ya, Shi, Jiahui, Ding, Chengtao, Wu, Gao, Sang, Zhihong, Wu, Qiang, Wang, Hua, Wu, Mian, Zhang, Zhiyong, Pan, Xin, Pan, Yue-yin, Gao, Ping, Zhang, Huafeng, Zhou, Cong-zhao, Guo, Jing, Yang, Zhenye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895051/
https://www.ncbi.nlm.nih.gov/pubmed/31804482
http://dx.doi.org/10.1038/s41467-019-13485-8

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