Multiple sclerosis drug FTY-720 toxicity is mediated by the heterotypic fusion of organelles in neuroendocrine cells

FTY-720 (Fingolimod) was one of the first compounds authorized for the treatment of multiple sclerosis. Among its other activities, this sphingosine analogue enhances exocytosis in neuroendocrine chromaffin cells, altering the quantal release of catecholamines. Surprisingly, the size of chromaffin g...

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Detalles Bibliográficos
Autores principales: Gimenez-Molina, Yolanda, García-Martínez, Virginia, Villanueva, José, Davletov, Bazbek, Gutiérrez, Luis M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895052/
https://www.ncbi.nlm.nih.gov/pubmed/31804600
http://dx.doi.org/10.1038/s41598-019-55106-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895052/
https://www.ncbi.nlm.nih.gov/pubmed/31804600
http://dx.doi.org/10.1038/s41598-019-55106-w

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