Cargando…

Common genetic variants associated with Parkinson’s disease display widespread signature of epigenetic plasticity

Parkinson disease (PD) is characterized by a pivotal progressive loss of substantia nigra dopaminergic neurons and aggregation of α-synuclein protein encoded by the SNCA gene. Genome-wide association studies identified almost 100 sequence variants linked to PD in SNCA. However, the consequences of t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sharma, Amit, Osato, Naoki, Liu, Hongde, Asthana, Shailendra, Dakal, Tikam Chand, Ambrosini, Giovanna, Bucher, Philipp, Schmitt, Ina, Wüllner, Ullrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895091/ https://www.ncbi.nlm.nih.gov/pubmed/31804560 http://dx.doi.org/10.1038/s41598-019-54865-w

Ejemplares similares

Advanced glycation end products and protein carbonyl levels in plasma reveal sex-specific differences in Parkinson's and Alzheimer's disease
por: Sharma, Amit, et al.
Publicado: (2020)

Ubiquitin Carboxyl-Terminal Hydrolases (UCHs): Potential Mediators for Cancer and Neurodegeneration
por: Sharma, Amit, et al.
Publicado: (2020)

SARS-CoV-2 attachment to host cells is possibly mediated via RGD-integrin interaction in a calcium-dependent manner and suggests pulmonary EDTA chelation therapy as a novel treatment for COVID 19
por: Dakal, Tikam Chand
Publicado: (2021)

Antigenic sites in SARS-CoV-2 spike RBD show molecular similarity with pathogenic antigenic determinants and harbors peptides for vaccine development
por: Dakal, Tikam Chand
Publicado: (2021)

Contrasting Patterns of rDNA Homogenization within the Zygosaccharomyces rouxii Species Complex
por: Chand Dakal, Tikam, et al.
Publicado: (2016)

Sex-Determination System in the Diploid Yeast Zygosaccharomyces sapae
por: Solieri, Lisa, et al.
Publicado: (2014)

Mechanistic Basis of Antimicrobial Actions of Silver Nanoparticles
por: Dakal, Tikam Chand, et al.
Publicado: (2016)

Towards a Central Role of ISL1 in the Bladder Exstrophy–Epispadias Complex (BEEC): Computational Characterization of Genetic Variants and Structural Modelling
por: Sharma, Amit, et al.
Publicado: (2018)

Genome organization in proximity to the BAP1 locus appears to play a pivotal role in a variety of cancers
por: Sharma, Amit, et al.
Publicado: (2020)

Crosstalk between β-Catenin and CCL2 Drives Migration of Monocytes towards Glioblastoma Cells
por: Aretz, Philippe, et al.
Publicado: (2022)

Analysis of the Adomian decomposition method to estimate the COVID-19 pandemic
por: Agarwal, Garima, et al.
Publicado: (2022)

Increased diversity of Malassezia species on the skin of Parkinson’s disease patients
por: Han, Xinyu, et al.
Publicado: (2023)

Anti-inflammatory activity of nicotine isolated from Brassica oleracea in rheumatoid arthritis
por: Rakhecha, Bharti, et al.
Publicado: (2022)

Epigenetic Analysis in Human Neurons: Considerations for Disease Modeling in PD
por: de Boni, Laura, et al.
Publicado: (2019)

Differential hypersaline stress response inZygosaccharomyces rouxiicomplex yeasts: a physiological and transcriptional study
por: Solieri, Lisa, et al.
Publicado: (2016)

Epigenetic and gene expression changes of neuronal cells from MSA patients are pronounced in enzymes for cell metabolism and calcium-regulated protein kinases
por: de Boni, Laura, et al.
Publicado: (2021)

Predicting the functional consequences of non-synonymous single nucleotide polymorphisms in IL8 gene
por: Dakal, Tikam Chand, et al.
Publicado: (2017)

Systematic discrimination of the repetitive genome in proximity of ferroptosis genes and a novel prognostic signature correlating with the oncogenic lncRNA CRNDE in multiple myeloma
por: Qin, Jiading, et al.
Publicado: (2022)

Epigenome-Wide Analysis of DNA Methylation in Parkinson’s Disease Cortex
por: Kaut, Oliver, et al.
Publicado: (2022)

Systematic integration of m6A regulators and autophagy-related genes in combination with long non-coding RNAs predicts survival in glioblastoma multiforme
por: Sharma, Amit, et al.
Publicado: (2023)

Non-oncology drug (meticrane) shows anti-cancer ability in synergy with epigenetic inhibitors and appears to be involved passively in targeting cancer cells
por: Wang, Yulu, et al.
Publicado: (2023)

Mutational Landscape of the BAP1 Locus Reveals an Intrinsic Control to Regulate the miRNA Network and the Binding of Protein Complexes in Uveal Melanoma
por: Sharma, Amit, et al.
Publicado: (2019)

Cleroda-4(18),13-dien-15,16-olide as novel xanthine oxidase inhibitors: An integrated in silico and in vitro study
por: Nguyen, Ha Thi, et al.
Publicado: (2021)

Candida albicans repetitive elements display epigenetic diversity and plasticity
por: Freire-Benéitez, Verónica, et al.
Publicado: (2016)

High throughput compound screening in neuronal cells identifies statins as activators of ataxin 3 expression
por: Stahl, Fabian, et al.
Publicado: (2023)

PPAR-Responsive Elements Enriched with Alu Repeats May Contribute to Distinctive PPARγ–DNMT1 Interactions in the Genome
por: Sharma, Amit, et al.
Publicado: (2021)

Regulator of G Protein Signaling 20 Correlates with Long Intergenic Non-Coding RNA (lincRNAs) Harboring Oncogenic Potential and Is Markedly Upregulated in Hepatocellular Carcinoma
por: Wang, Yulu, et al.
Publicado: (2022)

Potential anti-hepatocellular carcinoma properties and mechanisms of action of clerodane diterpenes isolated from Polyalthia longifolia seeds
por: Tatipamula, Vinay Bharadwaj, et al.
Publicado: (2022)

Are Epigenetic Factors Implicated in Chronic Widespread Pain?
por: Burri, Andrea, et al.
Publicado: (2016)

Genetic and epigenetic epidemiology of chronic widespread pain
por: Kerr, Jasmine I, et al.
Publicado: (2017)

Exosome-derived CIRP: An amplifier of inflammatory diseases
por: Han, Jingrun, et al.
Publicado: (2023)

Activators of alpha synuclein expression identified by reporter cell line-based high throughput drug screen
por: Stahl, Fabian, et al.
Publicado: (2021)

Plastic ingestion by marine fish is widespread and increasing
por: Savoca, Matthew S., et al.
Publicado: (2021)

Postural Stability in Parkinson's Disease Patients Is Improved after Stochastic Resonance Therapy
por: Kaut, Oliver, et al.
Publicado: (2016)

Life style and Parkinson’s disease
por: Reichmann, Heinz, et al.
Publicado: (2022)

Marginalizing the genomic architecture to identify crosstalk across cancer and neurodegeneration
por: Sharma, Amit, et al.
Publicado: (2023)

Widespread plasticity in CTCF occupancy linked to DNA methylation
por: Wang, Hao, et al.
Publicado: (2012)

Profiling of Epigenetic Features in Clinical Samples Reveals Novel Widespread Changes in Cancer
por: Noberini, Roberta, et al.
Publicado: (2019)

DNA methylation alterations in iPSC- and hESC-derived neurons: potential implications for neurological disease modeling
por: de Boni, Laura, et al.
Publicado: (2018)

SNP2TFBS – a database of regulatory SNPs affecting predicted transcription factor binding site affinity
por: Kumar, Sunil, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_pec24a2fl14ej4gpov92adfj67