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MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer’s disease models

Mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1) is an essential negative regulator of MAPKs by dephosphorylating MAPKs at both tyrosine and threonine residues. Dysregulation of the MAPK signaling pathway has been associated with Alzheimer’s disease (AD). However, the role of MKP-1 in A...

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Detalles Bibliográficos
Autores principales:	Du, Yehong, Du, Yexiang, Zhang, Yun, Huang, Zhilin, Fu, Min, Li, Junjie, Pang, Yayan, Lei, Peng, Wang, Yu Tian, Song, Weihong, He, Guiqiong, Dong, Zhifang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895219/ https://www.ncbi.nlm.nih.gov/pubmed/31840000 http://dx.doi.org/10.1038/s41392-019-0091-4

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