Draft Genome Sequences of Mycobacterium tuberculosis Clinical Isolates from the Ural Region of Russia That Carry the pks15/1 Gene

Here, we report the draft genome sequences of 15 Mycobacterium tuberculosis isolates of the Beijing-B0/W-148 sublineage that carry a 7-bp insertion within the pks15 gene, which leads to the synthesis of Pks15/1 fusion protein. Pks15/1 is involved in phenolglycolipid synthesis and biofilm formation,...

Descripción completa

Detalles Bibliográficos
Autores principales: Shur, Kirill V., Zakharevich, Natalia V., Akimova, Natalia I., Yunes, Roman A., Frolova, Svetlana G., Maslov, Dmitry A., Danilenko, Valery N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Genome Sequences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895303/
https://www.ncbi.nlm.nih.gov/pubmed/31806743
http://dx.doi.org/10.1128/MRA.01126-19
_version_ 1783476568113283072
author Shur, Kirill V.
Zakharevich, Natalia V.
Akimova, Natalia I.
Yunes, Roman A.
Frolova, Svetlana G.
Maslov, Dmitry A.
Danilenko, Valery N.
author_facet Shur, Kirill V.
Zakharevich, Natalia V.
Akimova, Natalia I.
Yunes, Roman A.
Frolova, Svetlana G.
Maslov, Dmitry A.
Danilenko, Valery N.
author_sort Shur, Kirill V.
collection PubMed
description Here, we report the draft genome sequences of 15 Mycobacterium tuberculosis isolates of the Beijing-B0/W-148 sublineage that carry a 7-bp insertion within the pks15 gene, which leads to the synthesis of Pks15/1 fusion protein. Pks15/1 is involved in phenolglycolipid synthesis and biofilm formation, thus potentially contributing to the B0/W-148 lineage’s enhanced virulence and drug resistance.
format Online
Article
Text
id pubmed-6895303
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher American Society for Microbiology
record_format MEDLINE/PubMed
spelling pubmed-68953032019-12-23 Draft Genome Sequences of Mycobacterium tuberculosis Clinical Isolates from the Ural Region of Russia That Carry the pks15/1 Gene Shur, Kirill V. Zakharevich, Natalia V. Akimova, Natalia I. Yunes, Roman A. Frolova, Svetlana G. Maslov, Dmitry A. Danilenko, Valery N. Microbiol Resour Announc Genome Sequences Here, we report the draft genome sequences of 15 Mycobacterium tuberculosis isolates of the Beijing-B0/W-148 sublineage that carry a 7-bp insertion within the pks15 gene, which leads to the synthesis of Pks15/1 fusion protein. Pks15/1 is involved in phenolglycolipid synthesis and biofilm formation, thus potentially contributing to the B0/W-148 lineage’s enhanced virulence and drug resistance. American Society for Microbiology 2019-12-05 /pmc/articles/PMC6895303/ /pubmed/31806743 http://dx.doi.org/10.1128/MRA.01126-19 Text en Copyright © 2019 Shur et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Genome Sequences
Shur, Kirill V.
Zakharevich, Natalia V.
Akimova, Natalia I.
Yunes, Roman A.
Frolova, Svetlana G.
Maslov, Dmitry A.
Danilenko, Valery N.
Draft Genome Sequences of Mycobacterium tuberculosis Clinical Isolates from the Ural Region of Russia That Carry the pks15/1 Gene
title Draft Genome Sequences of Mycobacterium tuberculosis Clinical Isolates from the Ural Region of Russia That Carry the pks15/1 Gene
title_full Draft Genome Sequences of Mycobacterium tuberculosis Clinical Isolates from the Ural Region of Russia That Carry the pks15/1 Gene
title_fullStr Draft Genome Sequences of Mycobacterium tuberculosis Clinical Isolates from the Ural Region of Russia That Carry the pks15/1 Gene
title_full_unstemmed Draft Genome Sequences of Mycobacterium tuberculosis Clinical Isolates from the Ural Region of Russia That Carry the pks15/1 Gene
title_short Draft Genome Sequences of Mycobacterium tuberculosis Clinical Isolates from the Ural Region of Russia That Carry the pks15/1 Gene
title_sort draft genome sequences of mycobacterium tuberculosis clinical isolates from the ural region of russia that carry the pks15/1 gene
topic Genome Sequences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895303/
https://www.ncbi.nlm.nih.gov/pubmed/31806743
http://dx.doi.org/10.1128/MRA.01126-19
work_keys_str_mv AT shurkirillv draftgenomesequencesofmycobacteriumtuberculosisclinicalisolatesfromtheuralregionofrussiathatcarrythepks151gene
AT zakharevichnataliav draftgenomesequencesofmycobacteriumtuberculosisclinicalisolatesfromtheuralregionofrussiathatcarrythepks151gene
AT akimovanataliai draftgenomesequencesofmycobacteriumtuberculosisclinicalisolatesfromtheuralregionofrussiathatcarrythepks151gene
AT yunesromana draftgenomesequencesofmycobacteriumtuberculosisclinicalisolatesfromtheuralregionofrussiathatcarrythepks151gene
AT frolovasvetlanag draftgenomesequencesofmycobacteriumtuberculosisclinicalisolatesfromtheuralregionofrussiathatcarrythepks151gene
AT maslovdmitrya draftgenomesequencesofmycobacteriumtuberculosisclinicalisolatesfromtheuralregionofrussiathatcarrythepks151gene
AT danilenkovaleryn draftgenomesequencesofmycobacteriumtuberculosisclinicalisolatesfromtheuralregionofrussiathatcarrythepks151gene

Ejemplares similares