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Urinary Transforming Growth Factor-Beta 1 (uTGF-β1) and Prevalent CKD Risk in HIV-Positive Patients in West Africa
INTRODUCTION: This study investigated the association of urinary transforming growth factor-β1 (uTGF-β1) with prevalent chronic kidney disease (CKD) in the HIV-infected population. METHODS: HIV-positive patients without CKD (HIV(+)CKD(−), n = 194) and 114 with CKD (HIV(+)CKD(+)) who did not have hyp...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895576/ https://www.ncbi.nlm.nih.gov/pubmed/31844806 http://dx.doi.org/10.1016/j.ekir.2019.07.011 |
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author | Ekrikpo, Udeme E. Okuku, Cecilia N. Ajayi, Samuel O. Ayodele, Olugbenga E. Bello, Aminu K. Wonkam, Ambroise Dandara, Collet Kengne, Andre-Pascal Okpechi, Ikechi |
author_facet | Ekrikpo, Udeme E. Okuku, Cecilia N. Ajayi, Samuel O. Ayodele, Olugbenga E. Bello, Aminu K. Wonkam, Ambroise Dandara, Collet Kengne, Andre-Pascal Okpechi, Ikechi |
author_sort | Ekrikpo, Udeme E. |
collection | PubMed |
description | INTRODUCTION: This study investigated the association of urinary transforming growth factor-β1 (uTGF-β1) with prevalent chronic kidney disease (CKD) in the HIV-infected population. METHODS: HIV-positive patients without CKD (HIV(+)CKD(−), n = 194) and 114 with CKD (HIV(+)CKD(+)) who did not have hypertension, diabetes mellitus, or hepatitis B or C, had their urinary protein-creatinine ratio (uPCR), serum transforming growth factor (TGF)–β1, and uTGF-β1 measured. uTGF-β1-creatinine ratios (uTGF-β1Cr) were calculated. Spearman correlation was used to determine the association between uTGF-β1Cr and various attributes, and the Cuzick trend test was used to assess the presence of a linear trend in median uTGF-β1Cr levels across the stages of CKD. Multivariable robust linear regression models were used to assess independent association with variability in uTGF-β1Cr and estimated glomerular filtration rate (eGFR) levels. RESULTS: The age of the participants was 38.3 ± 10.3 years with 73.4% women. The median uTGF-β1Cr was higher among HIV(+)CKD(+) (4.85 ng/mmol [25th–75th percentile 1.96–12.35] vs. 2.95 [1.02–5.84]; P = 0.001]). There was significant correlation between uTGF-β1Cr and age (P = 0.02), eGFR (P = 0.001), and uPCR (P < 0.001) in the HIV(+)CKD(+) group. Among the HIV(+)CKD(+) patients, there was gradual reduction in the median level of uTGF-β1Cr with CKD severity (P = 0.04). HIV(+)CKD(+) patients had significantly higher levels of uTGF-β1Cr after controlling for potential confounders. Using eGFR as dependent variable, proteinuria explained the changes associated with uTGF-β1Cr levels. CONCLUSION: HIV(+)CKD(+) patients express higher levels of uTGF-β1 especially in the early stages of CKD apparently related to proteinuria levels. |
format | Online Article Text |
id | pubmed-6895576 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-68955762019-12-16 Urinary Transforming Growth Factor-Beta 1 (uTGF-β1) and Prevalent CKD Risk in HIV-Positive Patients in West Africa Ekrikpo, Udeme E. Okuku, Cecilia N. Ajayi, Samuel O. Ayodele, Olugbenga E. Bello, Aminu K. Wonkam, Ambroise Dandara, Collet Kengne, Andre-Pascal Okpechi, Ikechi Kidney Int Rep Clinical Research INTRODUCTION: This study investigated the association of urinary transforming growth factor-β1 (uTGF-β1) with prevalent chronic kidney disease (CKD) in the HIV-infected population. METHODS: HIV-positive patients without CKD (HIV(+)CKD(−), n = 194) and 114 with CKD (HIV(+)CKD(+)) who did not have hypertension, diabetes mellitus, or hepatitis B or C, had their urinary protein-creatinine ratio (uPCR), serum transforming growth factor (TGF)–β1, and uTGF-β1 measured. uTGF-β1-creatinine ratios (uTGF-β1Cr) were calculated. Spearman correlation was used to determine the association between uTGF-β1Cr and various attributes, and the Cuzick trend test was used to assess the presence of a linear trend in median uTGF-β1Cr levels across the stages of CKD. Multivariable robust linear regression models were used to assess independent association with variability in uTGF-β1Cr and estimated glomerular filtration rate (eGFR) levels. RESULTS: The age of the participants was 38.3 ± 10.3 years with 73.4% women. The median uTGF-β1Cr was higher among HIV(+)CKD(+) (4.85 ng/mmol [25th–75th percentile 1.96–12.35] vs. 2.95 [1.02–5.84]; P = 0.001]). There was significant correlation between uTGF-β1Cr and age (P = 0.02), eGFR (P = 0.001), and uPCR (P < 0.001) in the HIV(+)CKD(+) group. Among the HIV(+)CKD(+) patients, there was gradual reduction in the median level of uTGF-β1Cr with CKD severity (P = 0.04). HIV(+)CKD(+) patients had significantly higher levels of uTGF-β1Cr after controlling for potential confounders. Using eGFR as dependent variable, proteinuria explained the changes associated with uTGF-β1Cr levels. CONCLUSION: HIV(+)CKD(+) patients express higher levels of uTGF-β1 especially in the early stages of CKD apparently related to proteinuria levels. Elsevier 2019-07-27 /pmc/articles/PMC6895576/ /pubmed/31844806 http://dx.doi.org/10.1016/j.ekir.2019.07.011 Text en © 2019 International Society of Nephrology. Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Clinical Research Ekrikpo, Udeme E. Okuku, Cecilia N. Ajayi, Samuel O. Ayodele, Olugbenga E. Bello, Aminu K. Wonkam, Ambroise Dandara, Collet Kengne, Andre-Pascal Okpechi, Ikechi Urinary Transforming Growth Factor-Beta 1 (uTGF-β1) and Prevalent CKD Risk in HIV-Positive Patients in West Africa |
title | Urinary Transforming Growth Factor-Beta 1 (uTGF-β1) and Prevalent CKD Risk in HIV-Positive Patients in West Africa |
title_full | Urinary Transforming Growth Factor-Beta 1 (uTGF-β1) and Prevalent CKD Risk in HIV-Positive Patients in West Africa |
title_fullStr | Urinary Transforming Growth Factor-Beta 1 (uTGF-β1) and Prevalent CKD Risk in HIV-Positive Patients in West Africa |
title_full_unstemmed | Urinary Transforming Growth Factor-Beta 1 (uTGF-β1) and Prevalent CKD Risk in HIV-Positive Patients in West Africa |
title_short | Urinary Transforming Growth Factor-Beta 1 (uTGF-β1) and Prevalent CKD Risk in HIV-Positive Patients in West Africa |
title_sort | urinary transforming growth factor-beta 1 (utgf-β1) and prevalent ckd risk in hiv-positive patients in west africa |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895576/ https://www.ncbi.nlm.nih.gov/pubmed/31844806 http://dx.doi.org/10.1016/j.ekir.2019.07.011 |
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