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In search of the next super models
The advent of pluripotent stem cell biology and facile genetic manipulation via CRISPR technology has ushered in a new era of human disease models for drug discovery and development. While these precision “super models” hold great promise for tailoring personalized therapy, their full potential and...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895600/ https://www.ncbi.nlm.nih.gov/pubmed/31736275 http://dx.doi.org/10.15252/emmm.201911502 |
| _version_ | 1783476591716728832 |
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| author | Goedel, Alexander Grote Beverborg, Niels Sahara, Makoto Chien, Kenneth R |
| author_facet | Goedel, Alexander Grote Beverborg, Niels Sahara, Makoto Chien, Kenneth R |
| author_sort | Goedel, Alexander |
| collection | PubMed |
| description | The advent of pluripotent stem cell biology and facile genetic manipulation via CRISPR technology has ushered in a new era of human disease models for drug discovery and development. While these precision “super models” hold great promise for tailoring personalized therapy, their full potential and in vivo validation have remained elusive. |
| format | Online Article Text |
| id | pubmed-6895600 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-68956002019-12-16 In search of the next super models Goedel, Alexander Grote Beverborg, Niels Sahara, Makoto Chien, Kenneth R EMBO Mol Med News & Views The advent of pluripotent stem cell biology and facile genetic manipulation via CRISPR technology has ushered in a new era of human disease models for drug discovery and development. While these precision “super models” hold great promise for tailoring personalized therapy, their full potential and in vivo validation have remained elusive. John Wiley and Sons Inc. 2019-11-18 2019-12 /pmc/articles/PMC6895600/ /pubmed/31736275 http://dx.doi.org/10.15252/emmm.201911502 Text en © 2019 The Authors. Published under the terms of the CC BY 4.0 license This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | News & Views Goedel, Alexander Grote Beverborg, Niels Sahara, Makoto Chien, Kenneth R In search of the next super models |
| title | In search of the next super models |
| title_full | In search of the next super models |
| title_fullStr | In search of the next super models |
| title_full_unstemmed | In search of the next super models |
| title_short | In search of the next super models |
| title_sort | in search of the next super models |
| topic | News & Views |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895600/ https://www.ncbi.nlm.nih.gov/pubmed/31736275 http://dx.doi.org/10.15252/emmm.201911502 |
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