Immune‐mediated ECM depletion improves tumour perfusion and payload delivery

High extracellular matrix (ECM) content in solid cancers impairs tumour perfusion and thus access of imaging and therapeutic agents. We have devised a new approach to degrade tumour ECM, which improves uptake of circulating compounds. We target the immune‐modulating cytokine, tumour necrosis factor...

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Detalles Bibliográficos
Autores principales: Yeow, Yen Ling, Kotamraju, Venkata Ramana, Wang, Xiao, Chopra, Meenu, Azme, Nasibah, Wu, Jiansha, Schoep, Tobias D, Delaney, Derek S, Feindel, Kirk, Li, Ji, Kennedy, Kelsey M, Allen, Wes M, Kennedy, Brendan F, Larma, Irma, Sampson, David D, Mahakian, Lisa M, Fite, Brett Z, Zhang, Hua, Friman, Tomas, Mann, Aman P, Aziz, Farah A, Kumarasinghe, M Priyanthi, Johansson, Mikael, Ee, Hooi C, Yeoh, George, Mou, Lingjun, Ferrara, Katherine W, Billiran, Hector, Ganss, Ruth, Ruoslahti, Erkki, Hamzah, Juliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895610/
https://www.ncbi.nlm.nih.gov/pubmed/31709774
http://dx.doi.org/10.15252/emmm.201910923

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