Cargando…

The mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma

The mitochondrial deoxynucleotide triphosphate (dNTP) is maintained by the mitochondrial deoxynucleoside salvage pathway and dedicated for the mtDNA homeostasis, and the mitochondrial deoxyguanosine kinase (DGUOK) is a rate‐limiting enzyme in this pathway. Here, we investigated the role of the DGUOK...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Shengchen, Huang, Chongbiao, Sun, Jianwei, Bollt, Oana, Wang, Xiuchao, Martine, Eric, Kang, Jiaxin, Taylor, Matthew D, Fang, Bin, Singh, Pankaj K, Koomen, John, Hao, Jihui, Yang, Shengyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895611/ https://www.ncbi.nlm.nih.gov/pubmed/31633874 http://dx.doi.org/10.15252/emmm.201910849

Ejemplares similares

Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments
por: Lin, Shengchen, et al.
Publicado: (2019)

Mitochondrial Deoxyguanosine Kinase Regulates NAD(+) Biogenesis Independent of Mitochondria Complex I Activity
por: Sang, Lei, et al.
Publicado: (2020)

Deoxyguanosine kinase mutation producing juvenile-onset mitochondrial myopathy
por: Komal, F.N.U., et al.
Publicado: (2018)

IL-37/ STAT3/ HIF-1α negative feedback signaling drives gemcitabine resistance in pancreatic cancer
por: Zhao, Tiansuo, et al.
Publicado: (2020)

Tumour-derived Interleukin 35 promotes pancreatic ductal adenocarcinoma cell extravasation and metastasis by inducing ICAM1 expression
por: Huang, Chongbiao, et al.
Publicado: (2017)

Tumoral EHF predicts the efficacy of anti-PD1 therapy in pancreatic ductal adenocarcinoma
por: Liu, Jing, et al.
Publicado: (2019)

Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma
por: Zhao, Tiansuo, et al.
Publicado: (2014)

Correction: Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma
por: Zhao, Tiansuo, et al.
Publicado: (2019)

A fatal case of mitochondrial DNA depletion syndrome with novel compound heterozygous variants in the deoxyguanosine kinase gene
por: Fang, Weiyuan, et al.
Publicado: (2017)

Nuclear PLD1 combined with NPM1 induces gemcitabine resistance through tumorigenic IL7R in pancreatic adenocarcinoma
por: Fu, Danqi, et al.
Publicado: (2023)

Deoxyguanosine kinase deficiency and recurrent spontaneous pneumothorax: a case report
por: Ramboux, Alice, et al.
Publicado: (2023)

Disseminating melanoma cells surf on calcium waves
por: Sun, Jianwei, et al.
Publicado: (2015)

8-hydroxy-2′-deoxyguanosine in colorectal adenocarcinoma – is it a result of oxidative stress?
por: Płachetka, Anna, et al.
Publicado: (2013)

Deoxyguanosine kinase mutation F180S is associated with a lean phenotype in mice
por: Borreguero, Cédric Francis, et al.
Publicado: (2023)

The Deoxynucleoside Triphosphate Triphosphohydrolase Activity of SAMHD1 Protein Contributes to the Mitochondrial DNA Depletion Associated with Genetic Deficiency of Deoxyguanosine Kinase
por: Franzolin, Elisa, et al.
Publicado: (2015)

Single nucleotide polymorphism in the microRNA-199a binding site of HIF1A gene is associated with pancreatic ductal adenocarcinoma risk and worse clinical outcomes
por: Wang, Xiuchao, et al.
Publicado: (2016)

ESE3-positive PSCs drive pancreatic cancer fibrosis, chemoresistance and poor prognosis via tumour–stromal IL-1β/NF–κB/ESE3 signalling axis
por: Zhao, Tiansuo, et al.
Publicado: (2022)

Mitochondrial 8-hydroxy-2′-deoxyguanosine and coronary artery disease in patients with type 2 diabetes mellitus
por: Wang, Xue-bin, et al.
Publicado: (2020)

Deoxyguanosine is a TLR7 agonist
por: Davenne, Tamara, et al.
Publicado: (2019)

BICC1 drives pancreatic cancer progression by inducing VEGF-independent angiogenesis
por: Huang, Chongbiao, et al.
Publicado: (2023)

Serum insulin‐like growth factor binding protein 2 levels as biomarker for pancreatic ductal adenocarcinoma‐associated malnutrition and muscle wasting
por: Dong, Jie, et al.
Publicado: (2021)

Characterization of the Deoxyguanosine–Lysine Cross-Link of Methylglyoxal
por: Petrova, Katya V., et al.
Publicado: (2014)

Important Requirements for Desorption/Ionization Mass Spectrometric Measurements of Temozolomide-Induced 2′-Deoxyguanosine Methylations in DNA
por: Fresnais, Margaux, et al.
Publicado: (2023)

8-Oxo-7,8-dihydro-2'-deoxyguanosine Forms a Relatively Unstable Tetrameric Structure Compared with 2'-Deoxyguanosine
por: Iwahashi, Hideo
Publicado: (2009)

PD-L1 is a direct target of cancer-FOXP3 in pancreatic ductal adenocarcinoma (PDAC), and combined immunotherapy with antibodies against PD-L1 and CCL5 is effective in the treatment of PDAC
por: Wang, Xiuchao, et al.
Publicado: (2020)

Biotinylation of Deoxyguanosine at the Abasic Site in Double-Stranded Oligodeoxynucleotides
por: Wu, Chun
Publicado: (2016)

Alpha-Deoxyguanosine to Reshape the Alpha-Thrombin Binding Aptamer
por: Kolganova, Natalia A., et al.
Publicado: (2023)

Structure and dynamics of the deoxyguanosine-sensing riboswitch studied by NMR-spectroscopy
por: Wacker, Anna, et al.
Publicado: (2011)

Structural principles of nucleoside selectivity in a 2′-deoxyguanosine riboswitch
por: Pikovskaya, Olga, et al.
Publicado: (2011)

The association constant of 5′,8-cyclo-2′-deoxyguanosine with cytidine
por: Capobianco, Amedeo, et al.
Publicado: (2015)

Identifying the Tautomeric Form of a Deoxyguanosine-Estrogen Quinone Intermediate
por: Stack, Douglas E.
Publicado: (2015)

Translesion Synthesis of 2′-Deoxyguanosine Lesions by Eukaryotic DNA Polymerases
por: Basu, Ashis K., et al.
Publicado: (2016)

Ligand binding to 2΄-deoxyguanosine sensing riboswitch in metabolic context
por: Kim, Yong-Boum, et al.
Publicado: (2017)

Irbesartan overcomes gemcitabine resistance in pancreatic cancer by suppressing stemness and iron metabolism via inhibition of the Hippo/YAP1/c-Jun axis
por: Zhou, Tianxing, et al.
Publicado: (2023)

8-Methyl-2′-deoxyguanosine incorporation into parallel DNA quadruplex structures
por: Virgilio, Antonella, et al.
Publicado: (2005)

A selective synthesis of 4-aminobiphenyl-N2-deoxyguanosine adducts.
por: Scheer, S, et al.
Publicado: (1994)

Synthetic and oxidative studies on 8-(arylamino)-2'-deoxyguanosine and -guanosine derivatives.
por: Johnson, F, et al.
Publicado: (1994)

Isostructural Self-Assembly of 2′-Deoxyguanosine Derivatives in Aqueous and Organic Media
por: García-Arriaga, Marilyn, et al.
Publicado: (2008)

Hexadecameric Self-Assembled Dendrimers Built from 2′-Deoxyguanosine Derivatives
por: Betancourt, José E., et al.
Publicado: (2008)

The Research of G–Motif Construction and Chirality in Deoxyguanosine Monophosphate Nucleotide Complexes
por: Zhu, Yanhong, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_4o766akq3jso56muuk0rvcodo9