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Morphological and Molecular Defects in Human Three-Dimensional Retinal Organoid Model of X-Linked Juvenile Retinoschisis

X-linked juvenile retinoschisis (XLRS), linked to mutations in the RS1 gene, is a degenerative retinopathy with a retinal splitting phenotype. We generated human induced pluripotent stem cells (hiPSCs) from patients to study XLRS in a 3D retinal organoid in vitro differentiation system. This model r...

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Detalles Bibliográficos
Autores principales:	Huang, Kang-Chieh, Wang, Mong-Lien, Chen, Shih-Jen, Kuo, Jean-Cheng, Wang, Won-Jing, Nhi Nguyen, Phan Nguyen, Wahlin, Karl J., Lu, Jyh-Feng, Tran, Audrey A., Shi, Michael, Chien, Yueh, Yarmishyn, Aliaksandr A., Tsai, Ping-Hsing, Yang, Tien-Chun, Jane, Wann-Neng, Chang, Chia-Ching, Peng, Chi-Hsien, Schlaeger, Thorsten M., Chiou, Shih-Hwa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895767/ https://www.ncbi.nlm.nih.gov/pubmed/31668851 http://dx.doi.org/10.1016/j.stemcr.2019.09.010

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