IL-33 Promotes CD11b/CD18-Mediated Adhesion of Eosinophils to Cancer Cells and Synapse-Polarized Degranulation Leading to Tumor Cell Killing

Eosinophils are major effectors of Th2-related pathologies, frequently found infiltrating several human cancers. We recently showed that eosinophils play an essential role in anti-tumor responses mediated by immunotherapy with the ‘alarmin’ intereukin-33 (IL-33) in melanoma mouse models. Here, we an...

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Detalles Bibliográficos
Autores principales: Andreone, Sara, Spadaro, Francesca, Buccione, Carla, Mancini, Jacopo, Tinari, Antonella, Sestili, Paola, Gambardella, Adriana Rosa, Lucarini, Valeria, Ziccheddu, Giovanna, Parolini, Isabella, Zanetti, Cristiana, D’Urso, Maria Teresa, De Ninno, Adele, Businaro, Luca, Afferni, Claudia, Mattei, Fabrizio, Schiavoni, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895824/
https://www.ncbi.nlm.nih.gov/pubmed/31717819
http://dx.doi.org/10.3390/cancers11111664

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