Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA

Type II DNA topoisomerase enzymes (TOP2) catalyze topological changes by strand passage reactions. They involve passing one intact double stranded DNA duplex through a transient enzyme-bridged break in another (gated helix) followed by ligation of the break by TOP2. A TOP2 poison, etoposide blocks T...

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Detalles Bibliográficos
Autores principales: Morimoto, Suguru, Tsuda, Masataka, Bunch, Heeyoun, Sasanuma, Hiroyuki, Austin, Caroline, Takeda, Shunichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895833/
https://www.ncbi.nlm.nih.gov/pubmed/31671674
http://dx.doi.org/10.3390/genes10110868

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895833/
https://www.ncbi.nlm.nih.gov/pubmed/31671674
http://dx.doi.org/10.3390/genes10110868

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