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Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA

Type II DNA topoisomerase enzymes (TOP2) catalyze topological changes by strand passage reactions. They involve passing one intact double stranded DNA duplex through a transient enzyme-bridged break in another (gated helix) followed by ligation of the break by TOP2. A TOP2 poison, etoposide blocks T...

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Detalles Bibliográficos
Autores principales:	Morimoto, Suguru, Tsuda, Masataka, Bunch, Heeyoun, Sasanuma, Hiroyuki, Austin, Caroline, Takeda, Shunichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895833/ https://www.ncbi.nlm.nih.gov/pubmed/31671674 http://dx.doi.org/10.3390/genes10110868

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