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Structural Implications of STAT3 and STAT5 SH2 Domain Mutations

Src Homology 2 (SH2) domains arose within metazoan signaling pathways and are involved in protein regulation of multiple pleiotropic cascades. In signal transducer and activator of transcription (STAT) proteins, SH2 domain interactions are critical for molecular activation and nuclear accumulation o...

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Detalles Bibliográficos
Autores principales:	de Araujo, Elvin D., Orlova, Anna, Neubauer, Heidi A., Bajusz, Dávid, Seo, Hyuk-Soo, Dhe-Paganon, Sirano, Keserű, György M., Moriggl, Richard, Gunning, Patrick T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6895964/ https://www.ncbi.nlm.nih.gov/pubmed/31717342 http://dx.doi.org/10.3390/cancers11111757

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