Cargando…

Intranasal Pregabalin Administration: A Review of the Literature and the Worldwide Spontaneous Reporting System of Adverse Drug Reactions

Background: It is repeatedly reported that pregabalin (PRG) and gabapentin feature a potential for abuse/misuse, predominantly in patients with former or active substance use disorder. The most common route of use is oral, though reports of sublingual, intravenous, rectal, and smoking administration...

Descripción completa

Detalles Bibliográficos
Autores principales: Elsayed, Mohamed, Zeiss, René, Gahr, Maximilian, Connemann, Bernhard J., Schönfeldt-Lecuona, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896010/
https://www.ncbi.nlm.nih.gov/pubmed/31766153
http://dx.doi.org/10.3390/brainsci9110322
_version_ 1783476684905775104
author Elsayed, Mohamed
Zeiss, René
Gahr, Maximilian
Connemann, Bernhard J.
Schönfeldt-Lecuona, Carlos
author_facet Elsayed, Mohamed
Zeiss, René
Gahr, Maximilian
Connemann, Bernhard J.
Schönfeldt-Lecuona, Carlos
author_sort Elsayed, Mohamed
collection PubMed
description Background: It is repeatedly reported that pregabalin (PRG) and gabapentin feature a potential for abuse/misuse, predominantly in patients with former or active substance use disorder. The most common route of use is oral, though reports of sublingual, intravenous, rectal, and smoking administration also exist. A narrative review was performed to provide an overview of current knowledge about nasal PRG use. Methods: A narrative review of the currently available literature of nasal PRG use was performed by searching the MEDLINE, EMBASE, and Web of Science databases. The abstracts and articles identified were reviewed and examined for relevance. Secondly, a request regarding reports of cases of nasal PRG administration was performed in the worldwide spontaneous reporting system of adverse drug reactions of the European Medicines Agency (EMA, EudraVigilance database). Results: The literature search resulted in two reported cases of nasal PRG use. In the analysis of the EMA-database, 13 reported cases of nasal PRG use (11 male (two not specified), mean age of users = 34.2 years (four not specified)) were found. In two cases fatalities occurred related to PRG nasal use. Conclusions: Even if only little evidence can be found in current literature, the potential for misuse/abuse of PRG via nasal route might be of particular importance in the near future in PRG users who misuse it. Physicians should be aware of these alternative routes of administration.
format Online
Article
Text
id pubmed-6896010
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-68960102019-12-24 Intranasal Pregabalin Administration: A Review of the Literature and the Worldwide Spontaneous Reporting System of Adverse Drug Reactions Elsayed, Mohamed Zeiss, René Gahr, Maximilian Connemann, Bernhard J. Schönfeldt-Lecuona, Carlos Brain Sci Perspective Background: It is repeatedly reported that pregabalin (PRG) and gabapentin feature a potential for abuse/misuse, predominantly in patients with former or active substance use disorder. The most common route of use is oral, though reports of sublingual, intravenous, rectal, and smoking administration also exist. A narrative review was performed to provide an overview of current knowledge about nasal PRG use. Methods: A narrative review of the currently available literature of nasal PRG use was performed by searching the MEDLINE, EMBASE, and Web of Science databases. The abstracts and articles identified were reviewed and examined for relevance. Secondly, a request regarding reports of cases of nasal PRG administration was performed in the worldwide spontaneous reporting system of adverse drug reactions of the European Medicines Agency (EMA, EudraVigilance database). Results: The literature search resulted in two reported cases of nasal PRG use. In the analysis of the EMA-database, 13 reported cases of nasal PRG use (11 male (two not specified), mean age of users = 34.2 years (four not specified)) were found. In two cases fatalities occurred related to PRG nasal use. Conclusions: Even if only little evidence can be found in current literature, the potential for misuse/abuse of PRG via nasal route might be of particular importance in the near future in PRG users who misuse it. Physicians should be aware of these alternative routes of administration. MDPI 2019-11-13 /pmc/articles/PMC6896010/ /pubmed/31766153 http://dx.doi.org/10.3390/brainsci9110322 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Perspective
Elsayed, Mohamed
Zeiss, René
Gahr, Maximilian
Connemann, Bernhard J.
Schönfeldt-Lecuona, Carlos
Intranasal Pregabalin Administration: A Review of the Literature and the Worldwide Spontaneous Reporting System of Adverse Drug Reactions
title Intranasal Pregabalin Administration: A Review of the Literature and the Worldwide Spontaneous Reporting System of Adverse Drug Reactions
title_full Intranasal Pregabalin Administration: A Review of the Literature and the Worldwide Spontaneous Reporting System of Adverse Drug Reactions
title_fullStr Intranasal Pregabalin Administration: A Review of the Literature and the Worldwide Spontaneous Reporting System of Adverse Drug Reactions
title_full_unstemmed Intranasal Pregabalin Administration: A Review of the Literature and the Worldwide Spontaneous Reporting System of Adverse Drug Reactions
title_short Intranasal Pregabalin Administration: A Review of the Literature and the Worldwide Spontaneous Reporting System of Adverse Drug Reactions
title_sort intranasal pregabalin administration: a review of the literature and the worldwide spontaneous reporting system of adverse drug reactions
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896010/
https://www.ncbi.nlm.nih.gov/pubmed/31766153
http://dx.doi.org/10.3390/brainsci9110322
work_keys_str_mv AT elsayedmohamed intranasalpregabalinadministrationareviewoftheliteratureandtheworldwidespontaneousreportingsystemofadversedrugreactions
AT zeissrene intranasalpregabalinadministrationareviewoftheliteratureandtheworldwidespontaneousreportingsystemofadversedrugreactions
AT gahrmaximilian intranasalpregabalinadministrationareviewoftheliteratureandtheworldwidespontaneousreportingsystemofadversedrugreactions
AT connemannbernhardj intranasalpregabalinadministrationareviewoftheliteratureandtheworldwidespontaneousreportingsystemofadversedrugreactions
AT schonfeldtlecuonacarlos intranasalpregabalinadministrationareviewoftheliteratureandtheworldwidespontaneousreportingsystemofadversedrugreactions