Secondary Somatic Mutations in G-Protein-Related Pathways and Mutation Signatures in Uveal Melanoma

Background: Uveal melanoma (UM), a rare cancer of the eye, is characterized by initiating mutations in the genes G-protein subunit alpha Q (GNAQ), G-protein subunit alpha 11 (GNA11), cysteinyl leukotriene receptor 2 (CYSLTR2), and phospholipase C beta 4 (PLCB4) and by metastasis-promoting mutations...

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Detalles Bibliográficos
Autores principales: Piaggio, Francesca, Tozzo, Veronica, Bernardi, Cinzia, Croce, Michela, Puzone, Roberto, Viaggi, Silvia, Patrone, Serena, Barla, Annalisa, Coviello, Domenico, J. Jager, Martine, van der Velden, Pieter A., Zeschnigk, Michael, Cangelosi, Davide, Eva, Alessandra, Pfeffer, Ulrich, Amaro, Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896012/
https://www.ncbi.nlm.nih.gov/pubmed/31671564
http://dx.doi.org/10.3390/cancers11111688

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