Amantadine Improves Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning: A Case Report

Carbon monoxide (CO) poisoning causes severe brain damage, including delayed neuropsychiatric sequelae (DNS), which occur after a lucid interval following recovery from the insult of acute CO poisoning. We describe a 39-year-old male who developed DNS, including gait disturbance, trunk ataxia, and f...

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Autores principales: Nakano, Tomosuke, Hasegawa, Toshiki, Suzuki, Dai, Motomura, Eishi, Okada, Motohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896018/
https://www.ncbi.nlm.nih.gov/pubmed/31731567
http://dx.doi.org/10.3390/brainsci9110292
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author Nakano, Tomosuke
Hasegawa, Toshiki
Suzuki, Dai
Motomura, Eishi
Okada, Motohiro
author_facet Nakano, Tomosuke
Hasegawa, Toshiki
Suzuki, Dai
Motomura, Eishi
Okada, Motohiro
author_sort Nakano, Tomosuke
collection PubMed
description Carbon monoxide (CO) poisoning causes severe brain damage, including delayed neuropsychiatric sequelae (DNS), which occur after a lucid interval following recovery from the insult of acute CO poisoning. We describe a 39-year-old male who developed DNS, including gait disturbance, trunk ataxia, and fecal/urine incontinence, after remission of acute CO poisoning. Furthermore, he showed confusion, with disorientation in terms of time and space. All symptoms, including cognitive impairment, were dramatically improved by amantadine monotherapy. The present case illustrates the possibility of amantadine treatment for cognitive impairment as well as Parkinsonism induced by CO poisoning.
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spelling pubmed-68960182019-12-24 Amantadine Improves Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning: A Case Report Nakano, Tomosuke Hasegawa, Toshiki Suzuki, Dai Motomura, Eishi Okada, Motohiro Brain Sci Case Report Carbon monoxide (CO) poisoning causes severe brain damage, including delayed neuropsychiatric sequelae (DNS), which occur after a lucid interval following recovery from the insult of acute CO poisoning. We describe a 39-year-old male who developed DNS, including gait disturbance, trunk ataxia, and fecal/urine incontinence, after remission of acute CO poisoning. Furthermore, he showed confusion, with disorientation in terms of time and space. All symptoms, including cognitive impairment, were dramatically improved by amantadine monotherapy. The present case illustrates the possibility of amantadine treatment for cognitive impairment as well as Parkinsonism induced by CO poisoning. MDPI 2019-10-25 /pmc/articles/PMC6896018/ /pubmed/31731567 http://dx.doi.org/10.3390/brainsci9110292 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Nakano, Tomosuke
Hasegawa, Toshiki
Suzuki, Dai
Motomura, Eishi
Okada, Motohiro
Amantadine Improves Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning: A Case Report
title Amantadine Improves Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning: A Case Report
title_full Amantadine Improves Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning: A Case Report
title_fullStr Amantadine Improves Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning: A Case Report
title_full_unstemmed Amantadine Improves Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning: A Case Report
title_short Amantadine Improves Delayed Neuropsychiatric Sequelae of Carbon Monoxide Poisoning: A Case Report
title_sort amantadine improves delayed neuropsychiatric sequelae of carbon monoxide poisoning: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896018/
https://www.ncbi.nlm.nih.gov/pubmed/31731567
http://dx.doi.org/10.3390/brainsci9110292
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