Role of Sphingosylphosphorylcholine in Tumor and Tumor Microenvironment

Sphingosylphosphorylcholine (SPC) is a unique type of lysosphingolipid found in some diseases, and has been studied in cardiovascular, neurological, and inflammatory phenomena. In particular, SPC’s studies on cancer have been conducted mainly in terms of effects on cancer cells, and relatively littl...

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Detalles Bibliográficos
Autores principales: Park, Mi Kyung, Lee, Chang Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896196/
https://www.ncbi.nlm.nih.gov/pubmed/31683697
http://dx.doi.org/10.3390/cancers11111696
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author Park, Mi Kyung
Lee, Chang Hoon
author_facet Park, Mi Kyung
Lee, Chang Hoon
author_sort Park, Mi Kyung
collection PubMed
description Sphingosylphosphorylcholine (SPC) is a unique type of lysosphingolipid found in some diseases, and has been studied in cardiovascular, neurological, and inflammatory phenomena. In particular, SPC’s studies on cancer have been conducted mainly in terms of effects on cancer cells, and relatively little consideration has been given to aspects of tumor microenvironment. This review summarizes the effects of SPC on cancer and tumor microenvironment, and presents the results and prospects of modulators that regulate the various actions of SPC.
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spelling pubmed-68961962019-12-23 Role of Sphingosylphosphorylcholine in Tumor and Tumor Microenvironment Park, Mi Kyung Lee, Chang Hoon Cancers (Basel) Review Sphingosylphosphorylcholine (SPC) is a unique type of lysosphingolipid found in some diseases, and has been studied in cardiovascular, neurological, and inflammatory phenomena. In particular, SPC’s studies on cancer have been conducted mainly in terms of effects on cancer cells, and relatively little consideration has been given to aspects of tumor microenvironment. This review summarizes the effects of SPC on cancer and tumor microenvironment, and presents the results and prospects of modulators that regulate the various actions of SPC. MDPI 2019-10-31 /pmc/articles/PMC6896196/ /pubmed/31683697 http://dx.doi.org/10.3390/cancers11111696 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Park, Mi Kyung
Lee, Chang Hoon
Role of Sphingosylphosphorylcholine in Tumor and Tumor Microenvironment
title Role of Sphingosylphosphorylcholine in Tumor and Tumor Microenvironment
title_full Role of Sphingosylphosphorylcholine in Tumor and Tumor Microenvironment
title_fullStr Role of Sphingosylphosphorylcholine in Tumor and Tumor Microenvironment
title_full_unstemmed Role of Sphingosylphosphorylcholine in Tumor and Tumor Microenvironment
title_short Role of Sphingosylphosphorylcholine in Tumor and Tumor Microenvironment
title_sort role of sphingosylphosphorylcholine in tumor and tumor microenvironment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896196/
https://www.ncbi.nlm.nih.gov/pubmed/31683697
http://dx.doi.org/10.3390/cancers11111696
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