NOS1 inhibits the interferon response of cancer cells by S-nitrosylation of HDAC2

BACKGROUND: The dysfunction of type I interferon (IFN) signaling is an important mechanism of immune escape and metastasis in tumors. Increased NOS1 expression has been detected in melanoma, which correlated with dysfunctional IFN signaling and poor response to immunotherapy, but the specific mechan...

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Detalles Bibliográficos
Autores principales: Xu, Pengfei, Ye, Shuangyan, Li, Keyi, Huang, Mengqiu, Wang, Qianli, Zeng, Sisi, Chen, Xi, Gao, Wenwen, Chen, Jianping, Zhang, Qianbing, Zhong, Zhuo, Lin, Ying, Rong, Zhili, Xu, Yang, Hao, Bingtao, Peng, Anghui, Ouyang, Manzhao, Liu, Qiuzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896289/
https://www.ncbi.nlm.nih.gov/pubmed/31805977
http://dx.doi.org/10.1186/s13046-019-1448-9

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