Severe necrotising inflammatory skin reaction to topical 5-fluorouracil

I report two patients who developed a severe necrotising inflammatory skin reaction with ulceration and hemorrhagic crusting during the first cycle of chemotherapy with 1% 5-Fluorouracil eye drops for Ocular surface squamous neoplasia. The skin reaction subsided on stoppage of the drops and the use...

Descripción completa

Detalles Bibliográficos
Autor principal: Gokhale, Nikhil S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896520/
https://www.ncbi.nlm.nih.gov/pubmed/31755461
http://dx.doi.org/10.4103/ijo.IJO_373_19
_version_ 1783476795970945024
author Gokhale, Nikhil S
author_facet Gokhale, Nikhil S
author_sort Gokhale, Nikhil S
collection PubMed
description I report two patients who developed a severe necrotising inflammatory skin reaction with ulceration and hemorrhagic crusting during the first cycle of chemotherapy with 1% 5-Fluorouracil eye drops for Ocular surface squamous neoplasia. The skin reaction subsided on stoppage of the drops and the use of a steroid ointment. 5 fluorouracil therapy was terminated and the patients were shifted to interferon therapy subsequently.
format Online
Article
Text
id pubmed-6896520
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-68965202020-01-09 Severe necrotising inflammatory skin reaction to topical 5-fluorouracil Gokhale, Nikhil S Indian J Ophthalmol Case Reports I report two patients who developed a severe necrotising inflammatory skin reaction with ulceration and hemorrhagic crusting during the first cycle of chemotherapy with 1% 5-Fluorouracil eye drops for Ocular surface squamous neoplasia. The skin reaction subsided on stoppage of the drops and the use of a steroid ointment. 5 fluorouracil therapy was terminated and the patients were shifted to interferon therapy subsequently. Wolters Kluwer - Medknow 2019-12 2019-11-22 /pmc/articles/PMC6896520/ /pubmed/31755461 http://dx.doi.org/10.4103/ijo.IJO_373_19 Text en Copyright: © 2019 Indian Journal of Ophthalmology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Reports
Gokhale, Nikhil S
Severe necrotising inflammatory skin reaction to topical 5-fluorouracil
title Severe necrotising inflammatory skin reaction to topical 5-fluorouracil
title_full Severe necrotising inflammatory skin reaction to topical 5-fluorouracil
title_fullStr Severe necrotising inflammatory skin reaction to topical 5-fluorouracil
title_full_unstemmed Severe necrotising inflammatory skin reaction to topical 5-fluorouracil
title_short Severe necrotising inflammatory skin reaction to topical 5-fluorouracil
title_sort severe necrotising inflammatory skin reaction to topical 5-fluorouracil
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896520/
https://www.ncbi.nlm.nih.gov/pubmed/31755461
http://dx.doi.org/10.4103/ijo.IJO_373_19
work_keys_str_mv AT gokhalenikhils severenecrotisinginflammatoryskinreactiontotopical5fluorouracil

Ejemplares similares