A cationic polymeric prodrug with chemotherapeutic self-sensibilization co-delivering MMP-9 shRNA plasmid for a combined therapy to nasopharyngeal carcinoma

To obtain a high-efficiency drug and gene co-delivery system to HNE-1 tumor therapy, a polymeric prodrug (PAAs-MTX) with chemotherapeutic sensibilization was synthesized consisting of a GSH-response hyperbranched poly(amido amine) (PAAs) and an antitumor drug of methotrexate (MTX). Then, the targeti...

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Detalles Bibliográficos
Autores principales: Liu, Tao, Wu, Xidong, Chen, Shaohua, Wu, Peina, Han, Hong, Zhang, Hongbin, Li, Junzheng, Li, Guanxue, Zhang, Siyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896581/
https://www.ncbi.nlm.nih.gov/pubmed/31793355
http://dx.doi.org/10.1080/10717544.2019.1698674

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