Haem oxygenase-1 induction prevents glucocorticoid-induced osteoblast apoptosis through activation of extracellular signal–regulated kinase1/2 signalling pathway

BACKGROUND: High-dose glucocorticoid (GC) therapy always causes osteoporosis partly by inducing osteoblast apoptosis. However, the underlying mechanisms of GC-induced apoptosis remain elusive. Haem oxygenase-1 (HO-1) is a cytoprotective protein that rescues cells from H(2)O(2) or high glucose–induce...

Descripción completa

Detalles Bibliográficos
Autores principales: Gu, Qiaoli, Chen, Mimi, Zhang, Yu, Huang, Yingkang, Yang, Huilin, Shi, Qin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Speaking Orthopaedic Society 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896674/
https://www.ncbi.nlm.nih.gov/pubmed/31844611
http://dx.doi.org/10.1016/j.jot.2019.04.003

Ejemplares similares

Ejemplares similares