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Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering
Recently, electrical stimulation as a physical stimulus draws lots of attention. It shows great potential in disease treatment, wound healing, and mechanism study because of significant experimental performance. Electrical stimulation can activate many intracellular signaling pathways, and influence...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896676/ https://www.ncbi.nlm.nih.gov/pubmed/31844552 http://dx.doi.org/10.1186/s40824-019-0176-8 |
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author | Chen, Cen Bai, Xue Ding, Yahui Lee, In-Seop |
author_facet | Chen, Cen Bai, Xue Ding, Yahui Lee, In-Seop |
author_sort | Chen, Cen |
collection | PubMed |
description | Recently, electrical stimulation as a physical stimulus draws lots of attention. It shows great potential in disease treatment, wound healing, and mechanism study because of significant experimental performance. Electrical stimulation can activate many intracellular signaling pathways, and influence intracellular microenvironment, as a result, affect cell migration, cell proliferation, and cell differentiation. Electrical stimulation is using in tissue engineering as a novel type of tool in regeneration medicine. Besides, with the advantages of biocompatible conductive materials coming into view, the combination of electrical stimulation with suitable tissue engineered scaffolds can well combine the benefits of both and is ideal for the field of regenerative medicine. In this review, we summarize the various materials and latest technologies to deliver electrical stimulation. The influences of electrical stimulation on cell alignment, migration and its underlying mechanisms are discussed. Then the effect of electrical stimulation on cell proliferation and differentiation are also discussed. |
format | Online Article Text |
id | pubmed-6896676 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-68966762019-12-16 Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering Chen, Cen Bai, Xue Ding, Yahui Lee, In-Seop Biomater Res Review Recently, electrical stimulation as a physical stimulus draws lots of attention. It shows great potential in disease treatment, wound healing, and mechanism study because of significant experimental performance. Electrical stimulation can activate many intracellular signaling pathways, and influence intracellular microenvironment, as a result, affect cell migration, cell proliferation, and cell differentiation. Electrical stimulation is using in tissue engineering as a novel type of tool in regeneration medicine. Besides, with the advantages of biocompatible conductive materials coming into view, the combination of electrical stimulation with suitable tissue engineered scaffolds can well combine the benefits of both and is ideal for the field of regenerative medicine. In this review, we summarize the various materials and latest technologies to deliver electrical stimulation. The influences of electrical stimulation on cell alignment, migration and its underlying mechanisms are discussed. Then the effect of electrical stimulation on cell proliferation and differentiation are also discussed. BioMed Central 2019-12-05 /pmc/articles/PMC6896676/ /pubmed/31844552 http://dx.doi.org/10.1186/s40824-019-0176-8 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Review Chen, Cen Bai, Xue Ding, Yahui Lee, In-Seop Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering |
title | Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering |
title_full | Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering |
title_fullStr | Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering |
title_full_unstemmed | Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering |
title_short | Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering |
title_sort | electrical stimulation as a novel tool for regulating cell behavior in tissue engineering |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896676/ https://www.ncbi.nlm.nih.gov/pubmed/31844552 http://dx.doi.org/10.1186/s40824-019-0176-8 |
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