Cargando…

Inhibition of KPNB1 Inhibits Proliferation and Promotes Apoptosis of Chronic Myeloid Leukemia Cells Through Regulation of E2F1

BACKGROUND: Karyopherin-β1 (KPNB1) belongs to the karyopherin superfamily, which functions as shuttling proteins from the cytoplasm to nuclear. A high level of KPNB1 has been reported in various cancers which promotes cell proliferation and inhibits apoptosis. However, the role of KPNB1 in chronic m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Teng, Huang, Zhenglan, Huang, Ningshu, Peng, Yuhang, Gao, Miao, Wang, Xin, Feng, Wenli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896920/ https://www.ncbi.nlm.nih.gov/pubmed/31819526 http://dx.doi.org/10.2147/OTT.S210048

Ejemplares similares

Blockade of Y177 and Nuclear Translocation of Bcr-Abl Inhibits Proliferation and Promotes Apoptosis in Chronic Myeloid Leukemia Cells
por: Li, Qianyin, et al.
Publicado: (2017)

Induction of apoptosis in imatinib sensitive and resistant chronic myeloid leukemia cells by efficient disruption of bcr-abl oncogene with zinc finger nucleases
por: Huang, Ningshu, et al.
Publicado: (2018)

Inhibition of YAP suppresses CML cell proliferation and enhances efficacy of imatinib in vitro and in vivo
por: Li, Hui, et al.
Publicado: (2016)

RanBP3 Regulates Proliferation, Apoptosis and Chemosensitivity of Chronic Myeloid Leukemia Cells via Mediating SMAD2/3 and ERK1/2 Nuclear Transport
por: Li, Qian, et al.
Publicado: (2021)

Efficient disruption of bcr-abl gene by CRISPR RNA-guided FokI nucleases depresses the oncogenesis of chronic myeloid leukemia cells
por: Luo, Zhenhong, et al.
Publicado: (2019)

Decreased KPNB1 Expression is Induced by PLK1 Inhibition and Leads to Apoptosis in Lung Adenocarcinoma
por: Sekimoto, Noboru, et al.
Publicado: (2017)

Effect of HSP90AB1 and CC domain interaction on Bcr-Abl protein cytoplasm localization and function in chronic myeloid leukemia cells
por: Peng, Yuhang, et al.
Publicado: (2021)

KPNB1 inhibition disrupts proteostasis and triggers unfolded protein response-mediated apoptosis in glioblastoma cells
por: Zhu, Zhi-Chuan, et al.
Publicado: (2018)

Inhibition of the ecto-beta subunit of F1F0-ATPase inhibits proliferation and induces apoptosis in acute myeloid leukemia cell lines
por: Wen-Li, Zhao, et al.
Publicado: (2012)

Modified dendritic cell-derived exosomes activate both NK cells and T cells through the NKG2D/NKG2D-L pathway to kill CML cells with or without T315I mutation
por: Du, Zhuanyun, et al.
Publicado: (2022)

A novel fusion circular RNA F-circBA1 derived from the BCR-ABL fusion gene displayed an oncogenic role in chronic myeloid leukemia cells
por: Tan, Yuan, et al.
Publicado: (2021)

TCF7 knockdown inhibits the imatinib resistance of chronic myeloid leukemia K562/G01 cells by neutralizing the Wnt/β-catenin/TCF7/ABC transporter signaling axis
por: Zhang, Hui, et al.
Publicado: (2021)

Disrupting myddosome assembly in diffuse large B-cell lymphoma cells using the MYD88 dimerization inhibitor ST2825
por: Wang, Xin, et al.
Publicado: (2019)

E2F1‑mediated RAB34 upregulation accelerates the proliferation and inhibits the cell cycle arrest and apoptosis of acute myeloid leukemia cells
por: Xiong, Xiaojie, et al.
Publicado: (2023)

LncRNA OIP5-AS1 Promotes the Autophagy-Related Imatinib Resistance in Chronic Myeloid Leukemia Cells by Regulating miR-30e-5p/ATG12 Axis
por: Dai, Hongdan, et al.
Publicado: (2021)

KPNB1 mediates PER/CRY nuclear translocation and circadian clock function
por: Lee, Yool, et al.
Publicado: (2015)

Intracellular delivery of anti-BCR/ABL antibody by PLGA nanoparticles suppresses the oncogenesis of chronic myeloid leukemia cells
por: Jiang, Guoyun, et al.
Publicado: (2021)

Inhibition of cystathionine β-synthase promotes apoptosis and reduces cell proliferation in chronic myeloid leukemia
por: Wang, Dan, et al.
Publicado: (2021)

Myeloid ecotropic viral integration site-1 inhibition promotes apoptosis, suppresses proliferation of acute myeloid leukemia cells, accentuates the effects of anticancer drugs
por: Jin, Yinglan, et al.
Publicado: (2022)

Unconventional tonicity-regulated nuclear trafficking of NFAT5 mediated by KPNB1, XPOT and RUVBL2
por: Cheung, Chris Y., et al.
Publicado: (2022)

Antitumor effects of pharmacological EZH2 inhibition on malignant peripheral nerve sheath tumor through the miR-30a and KPNB1 pathway
por: Zhang, Pingyu, et al.
Publicado: (2015)

Targeting KPNB1 overcomes TRAIL resistance by regulating DR5, Mcl-1 and FLIP in glioblastoma cells
por: Zhu, Zhi-Chuan, et al.
Publicado: (2019)

PCDH1 promotes progression of pancreatic ductal adenocarcinoma via activation of NF-κB signalling by interacting with KPNB1
por: Ye, Zhihua, et al.
Publicado: (2022)

microRNA-628 inhibits the proliferation of acute myeloid leukemia cells by directly targeting IGF-1R
por: Chen, Lu, et al.
Publicado: (2019)

Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells
por: Wu, Dang, et al.
Publicado: (2018)

KPNB1-mediated nuclear translocation of PD-L1 promotes non-small cell lung cancer cell proliferation via the Gas6/MerTK signaling pathway
por: Du, Wenwen, et al.
Publicado: (2020)

Notch2 inhibits proliferation of chronic myeloid leukemia cells
por: YANG, ZESONG, et al.
Publicado: (2013)

KPNB1-mediated nuclear import is required for motility and inflammatory transcription factor activity in cervical cancer cells
por: Stelma, Tamara, et al.
Publicado: (2017)

KPNB1 modulates the Machado–Joseph disease protein ataxin-3 through activation of the mitochondrial protease CLPP
por: Abeditashi, Mahkameh, et al.
Publicado: (2022)

Wee1 promotes cell proliferation and imatinib resistance in chronic myeloid leukemia via regulating DNA damage repair dependent on ATM-γH2AX-MDC1
por: Zeng, Fanting, et al.
Publicado: (2022)

Overexpression of MYCT1 Inhibits Proliferation and Induces Apoptosis in Human Acute Myeloid Leukemia HL-60 and KG-1a Cells in vitro and in vivo
por: Fu, Shuang, et al.
Publicado: (2018)

A novel coumarin derivative DBH2 inhibits proliferation and induces apoptosis of chronic myeloid leukemia cells
por: Xin, Jiajia, et al.
Publicado: (2022)

miR-4792 Inhibits Acute Myeloid Leukemia Cell Proliferation and Invasion and Promotes Cell Apoptosis by Targeting Kindlin-3
por: Qin, Yun, et al.
Publicado: (2020)

Casein kinase 1α inhibits p53 downstream of MDM2-mediated autophagy and apoptosis in acute myeloid leukemia
por: Xu, Wanling, et al.
Publicado: (2020)

Inhibition of CSRP2 Promotes Leukemia Cell Proliferation and Correlates with Relapse in Adults with Acute Myeloid Leukemia
por: Wang, Shujuan, et al.
Publicado: (2020)

Artesunate induces apoptosis and inhibits the proliferation, stemness, and tumorigenesis of leukemia
por: Chen, Shengmei, et al.
Publicado: (2020)

Downregulation of PDIA3 inhibits proliferation and invasion of human acute myeloid leukemia cells
por: Ye, Qidong, et al.
Publicado: (2018)

Targeting PDK1 with dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell growth
por: Qin, Lijun, et al.
Publicado: (2015)

TIGAR cooperated with glycolysis to inhibit the apoptosis of leukemia cells and associated with poor prognosis in patients with cytogenetically normal acute myeloid leukemia
por: Qian, Sixuan, et al.
Publicado: (2016)

CircBA1 derived from BCR‐ABL fusion gene inhibits cell proliferation in chronic myeloid leukemia
por: Wang, Jin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_rjj5cb8k2vkanb744npn70hg4h