Development, Testing, Parameterization, and Calibration of a Human Physiologically Based Pharmacokinetic Model for the Plasticizer, Hexamoll(®) Diisononyl-Cyclohexane-1, 2-Dicarboxylate Using In Silico, In Vitro, and Human Biomonitoring Data

A physiologically based pharmacokinetic model for Hexamoll(®) diisononyl-cyclohexane-1, 2-dicarboxylate was developed to interpret the biokinetics in humans after single oral doses. The model was parameterized with in vitro and in silico derived parameters and uncertainty and sensitivity analysis wa...

Descripción completa

Detalles Bibliográficos
Autores principales: McNally, Kevin, Sams, Craig, Loizou, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897292/
https://www.ncbi.nlm.nih.gov/pubmed/31849656
http://dx.doi.org/10.3389/fphar.2019.01394

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897292/
https://www.ncbi.nlm.nih.gov/pubmed/31849656
http://dx.doi.org/10.3389/fphar.2019.01394

Ejemplares similares