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Distinct rates and patterns of spread of the major HIV-1 subtypes in Central and East Africa

Since the ignition of the HIV-1 group M pandemic in the beginning of the 20th century, group M lineages have spread heterogeneously throughout the world. Subtype C spread rapidly through sub-Saharan Africa and is currently the dominant HIV lineage worldwide. Yet the epidemiological and evolutionary...

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Autores principales: Faria, Nuno R., Vidal, Nicole, Lourenco, José, Raghwani, Jayna, Sigaloff, Kim C. E., Tatem, Andy J., van de Vijver, David A. M., Pineda-Peña, Andrea-Clemencia, Rose, Rebecca, Wallis, Carole L., Ahuka-Mundeke, Steve, Muyembe-Tamfum, Jean-Jacques, Muwonga, Jérémie, Suchard, Marc A., Rinke de Wit, Tobias F., Hamers, Raph L., Ndembi, Nicaise, Baele, Guy, Peeters, Martine, Pybus, Oliver G., Lemey, Philippe, Dellicour, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897401/
https://www.ncbi.nlm.nih.gov/pubmed/31809523
http://dx.doi.org/10.1371/journal.ppat.1007976
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author Faria, Nuno R.
Vidal, Nicole
Lourenco, José
Raghwani, Jayna
Sigaloff, Kim C. E.
Tatem, Andy J.
van de Vijver, David A. M.
Pineda-Peña, Andrea-Clemencia
Rose, Rebecca
Wallis, Carole L.
Ahuka-Mundeke, Steve
Muyembe-Tamfum, Jean-Jacques
Muwonga, Jérémie
Suchard, Marc A.
Rinke de Wit, Tobias F.
Hamers, Raph L.
Ndembi, Nicaise
Baele, Guy
Peeters, Martine
Pybus, Oliver G.
Lemey, Philippe
Dellicour, Simon
author_facet Faria, Nuno R.
Vidal, Nicole
Lourenco, José
Raghwani, Jayna
Sigaloff, Kim C. E.
Tatem, Andy J.
van de Vijver, David A. M.
Pineda-Peña, Andrea-Clemencia
Rose, Rebecca
Wallis, Carole L.
Ahuka-Mundeke, Steve
Muyembe-Tamfum, Jean-Jacques
Muwonga, Jérémie
Suchard, Marc A.
Rinke de Wit, Tobias F.
Hamers, Raph L.
Ndembi, Nicaise
Baele, Guy
Peeters, Martine
Pybus, Oliver G.
Lemey, Philippe
Dellicour, Simon
author_sort Faria, Nuno R.
collection PubMed
description Since the ignition of the HIV-1 group M pandemic in the beginning of the 20th century, group M lineages have spread heterogeneously throughout the world. Subtype C spread rapidly through sub-Saharan Africa and is currently the dominant HIV lineage worldwide. Yet the epidemiological and evolutionary circumstances that contributed to its epidemiological expansion remain poorly understood. Here, we analyse 346 novel pol sequences from the DRC to compare the evolutionary dynamics of the main HIV-1 lineages, subtypes A1, C and D. Our results place the origins of subtype C in the 1950s in Mbuji-Mayi, the mining city of southern DRC, while subtypes A1 and D emerged in the capital city of Kinshasa, and subtypes H and J in the less accessible port city of Matadi. Following a 15-year period of local transmission in southern DRC, we find that subtype C spread at least three-fold faster than other subtypes circulating in Central and East Africa. In conclusion, our results shed light on the origins of HIV-1 main lineages and suggest that socio-historical rather than evolutionary factors may have determined the epidemiological fate of subtype C in sub-Saharan Africa.
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spelling pubmed-68974012019-12-13 Distinct rates and patterns of spread of the major HIV-1 subtypes in Central and East Africa Faria, Nuno R. Vidal, Nicole Lourenco, José Raghwani, Jayna Sigaloff, Kim C. E. Tatem, Andy J. van de Vijver, David A. M. Pineda-Peña, Andrea-Clemencia Rose, Rebecca Wallis, Carole L. Ahuka-Mundeke, Steve Muyembe-Tamfum, Jean-Jacques Muwonga, Jérémie Suchard, Marc A. Rinke de Wit, Tobias F. Hamers, Raph L. Ndembi, Nicaise Baele, Guy Peeters, Martine Pybus, Oliver G. Lemey, Philippe Dellicour, Simon PLoS Pathog Research Article Since the ignition of the HIV-1 group M pandemic in the beginning of the 20th century, group M lineages have spread heterogeneously throughout the world. Subtype C spread rapidly through sub-Saharan Africa and is currently the dominant HIV lineage worldwide. Yet the epidemiological and evolutionary circumstances that contributed to its epidemiological expansion remain poorly understood. Here, we analyse 346 novel pol sequences from the DRC to compare the evolutionary dynamics of the main HIV-1 lineages, subtypes A1, C and D. Our results place the origins of subtype C in the 1950s in Mbuji-Mayi, the mining city of southern DRC, while subtypes A1 and D emerged in the capital city of Kinshasa, and subtypes H and J in the less accessible port city of Matadi. Following a 15-year period of local transmission in southern DRC, we find that subtype C spread at least three-fold faster than other subtypes circulating in Central and East Africa. In conclusion, our results shed light on the origins of HIV-1 main lineages and suggest that socio-historical rather than evolutionary factors may have determined the epidemiological fate of subtype C in sub-Saharan Africa. Public Library of Science 2019-12-06 /pmc/articles/PMC6897401/ /pubmed/31809523 http://dx.doi.org/10.1371/journal.ppat.1007976 Text en © 2019 Faria et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Faria, Nuno R.
Vidal, Nicole
Lourenco, José
Raghwani, Jayna
Sigaloff, Kim C. E.
Tatem, Andy J.
van de Vijver, David A. M.
Pineda-Peña, Andrea-Clemencia
Rose, Rebecca
Wallis, Carole L.
Ahuka-Mundeke, Steve
Muyembe-Tamfum, Jean-Jacques
Muwonga, Jérémie
Suchard, Marc A.
Rinke de Wit, Tobias F.
Hamers, Raph L.
Ndembi, Nicaise
Baele, Guy
Peeters, Martine
Pybus, Oliver G.
Lemey, Philippe
Dellicour, Simon
Distinct rates and patterns of spread of the major HIV-1 subtypes in Central and East Africa
title Distinct rates and patterns of spread of the major HIV-1 subtypes in Central and East Africa
title_full Distinct rates and patterns of spread of the major HIV-1 subtypes in Central and East Africa
title_fullStr Distinct rates and patterns of spread of the major HIV-1 subtypes in Central and East Africa
title_full_unstemmed Distinct rates and patterns of spread of the major HIV-1 subtypes in Central and East Africa
title_short Distinct rates and patterns of spread of the major HIV-1 subtypes in Central and East Africa
title_sort distinct rates and patterns of spread of the major hiv-1 subtypes in central and east africa
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897401/
https://www.ncbi.nlm.nih.gov/pubmed/31809523
http://dx.doi.org/10.1371/journal.ppat.1007976
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