Intracerebroventricular administration of the thyroid hormone analog TRIAC increases its brain content in the absence of MCT8

Patients lacking the thyroid hormone (TH) transporter MCT8 present abnormal serum levels of TH: low thyroxine and high triiodothyronine. They also have severe neurodevelopmental defects resulting from cerebral hypothyroidism, most likely due to impaired TH transport across the brain barriers. The us...

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Detalles Bibliográficos
Autores principales: Bárez-López, Soledad, Grijota-Martínez, Carmen, Liao, Xiao-Hui, Refetoff, Samuel, Guadaño-Ferraz, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897405/
https://www.ncbi.nlm.nih.gov/pubmed/31809508
http://dx.doi.org/10.1371/journal.pone.0226017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897405/
https://www.ncbi.nlm.nih.gov/pubmed/31809508
http://dx.doi.org/10.1371/journal.pone.0226017

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