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Intracerebroventricular administration of the thyroid hormone analog TRIAC increases its brain content in the absence of MCT8
Patients lacking the thyroid hormone (TH) transporter MCT8 present abnormal serum levels of TH: low thyroxine and high triiodothyronine. They also have severe neurodevelopmental defects resulting from cerebral hypothyroidism, most likely due to impaired TH transport across the brain barriers. The us...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897405/ https://www.ncbi.nlm.nih.gov/pubmed/31809508 http://dx.doi.org/10.1371/journal.pone.0226017 |