Carboxylated branched poly(β-amino ester) nanoparticles enable robust cytosolic protein delivery and CRISPR-Cas9 gene editing

Efficient cytosolic protein delivery is necessary to fully realize the potential of protein therapeutics. Current methods of protein delivery often suffer from low serum tolerance and limited in vivo efficacy. Here, we report the synthesis and validation of a previously unreported class of carboxyla...

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Detalles Bibliográficos
Autores principales: Rui, Yuan, Wilson, David R., Choi, John, Varanasi, Mahita, Sanders, Katie, Karlsson, Johan, Lim, Michael, Green, Jordan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897553/
https://www.ncbi.nlm.nih.gov/pubmed/31840076
http://dx.doi.org/10.1126/sciadv.aay3255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897553/
https://www.ncbi.nlm.nih.gov/pubmed/31840076
http://dx.doi.org/10.1126/sciadv.aay3255

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