Placental malaria vaccine candidate antigen VAR2CSA displays atypical domain architecture in some Plasmodium falciparum strains

Two vaccines based on Plasmodium falciparum protein VAR2CSA are currently in clinical evaluation to prevent placental malaria (PM), but a deeper understanding of var2csa variability could impact vaccine design. Here we identified atypical extended or truncated VAR2CSA extracellular structures and co...

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Detalles Bibliográficos
Autores principales: Doritchamou, Justin Y. A., Morrison, Robert, Renn, Jonathan P., Ribeiro, Jose, Duan, Junhui, Fried, Michal, Duffy, Patrick E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897902/
https://www.ncbi.nlm.nih.gov/pubmed/31840102
http://dx.doi.org/10.1038/s42003-019-0704-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897902/
https://www.ncbi.nlm.nih.gov/pubmed/31840102
http://dx.doi.org/10.1038/s42003-019-0704-z

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