CytA, a reductase in the cytorhodin biosynthesis pathway, inactivates anthracycline drugs in Streptomyces

Antibiotic-producing microorganism can develop strategies to deal with self-toxicity. Cytorhodins X and Y, cosmomycins A and B, and iremycin, are produced as final products from a marine-derived Streptomyces sp. SCSIO 1666. These C-7 reduced metabolites show reduced antimicrobial and comparable cyto...

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Detalles Bibliográficos
Autores principales: Gui, Chun, Chen, Jiang, Xie, Qing, Mo, Xuhua, Zhang, Shanwen, Zhang, Hua, Ma, Junying, Li, Qinglian, Gu, Yu-Cheng, Ju, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897945/
https://www.ncbi.nlm.nih.gov/pubmed/31840099
http://dx.doi.org/10.1038/s42003-019-0699-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6897945/
https://www.ncbi.nlm.nih.gov/pubmed/31840099
http://dx.doi.org/10.1038/s42003-019-0699-5

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