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RAG-2 deficiency results in fewer phosphorylated histone H2AX foci, but increased retinal ganglion cell death and altered axonal growth
DNA double-strand breaks (DSBs), selectively visualized as γ-H2AX(+) foci, occur during the development of the central nervous system, including the retina, although their origin and biological significance are poorly understood. Mutant mice with DSB repair mechanism defects exhibit increased number...
Autores principales: | Álvarez-Lindo, Noemí, Baleriola, Jimena, de los Ríos, Vivian, Suárez, Teresa, de la Rosa, Enrique J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898044/ https://www.ncbi.nlm.nih.gov/pubmed/31811168 http://dx.doi.org/10.1038/s41598-019-54873-w |
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