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Understanding the diversity of genetic outcomes from CRISPR-Cas generated homology-directed repair

As CRISPR-Cas systems advance toward clinical application, it is essential to identify all the outcomes of gene-editing activity in human cells. Reports highlighting the remarkable success of homology-directed repair (HDR) in the treatment of inherited diseases may inadvertently underreport the coll...

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Detalles Bibliográficos
Autores principales:	Sansbury, Brett M., Hewes, Amanda M., Kmiec, Eric B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898364/ https://www.ncbi.nlm.nih.gov/pubmed/31840103 http://dx.doi.org/10.1038/s42003-019-0705-y

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