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Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals

Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies have reported heterogeneous results and it is not clear how the clinical heterogeneity is related to the observed differences...

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Autores principales: Favre, Pauline, Pauling, Melissa, Stout, Jacques, Hozer, Franz, Sarrazin, Samuel, Abé, Christoph, Alda, Martin, Alloza, Clara, Alonso-Lana, Silvia, Andreassen, Ole A., Baune, Bernhard T., Benedetti, Francesco, Busatto, Geraldo F., Canales-Rodríguez, Erick J., Caseras, Xavier, Chaim-Avancini, Tiffany Moukbel, Ching, Christopher R. K., Dannlowski, Udo, Deppe, Michael, Eyler, Lisa T., Fatjo-Vilas, Mar, Foley, Sonya F., Grotegerd, Dominik, Hajek, Tomas, Haukvik, Unn K., Howells, Fleur M., Jahanshad, Neda, Kugel, Harald, Lagerberg, Trine V., Lawrie, Stephen M., Linke, Julia O., McIntosh, Andrew, Melloni, Elisa M. T., Mitchell, Philip B., Polosan, Mircea, Pomarol-Clotet, Edith, Repple, Jonathan, Roberts, Gloria, Roos, Annerine, Rosa, Pedro G. P., Salvador, Raymond, Sarró, Salvador, Schofield, Peter R., Serpa, Mauricio H., Sim, Kang, Stein, Dan J., Sussmann, Jess E., Temmingh, Henk S., Thompson, Paul M., Verdolini, Norma, Vieta, Eduard, Wessa, Michele, Whalley, Heather C., Zanetti, Marcus V., Leboyer, Marion, Mangin, Jean-François, Henry, Chantal, Duchesnay, Edouard, Houenou, Josselin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898371/
https://www.ncbi.nlm.nih.gov/pubmed/31434102
http://dx.doi.org/10.1038/s41386-019-0485-6
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author Favre, Pauline
Pauling, Melissa
Stout, Jacques
Hozer, Franz
Sarrazin, Samuel
Abé, Christoph
Alda, Martin
Alloza, Clara
Alonso-Lana, Silvia
Andreassen, Ole A.
Baune, Bernhard T.
Benedetti, Francesco
Busatto, Geraldo F.
Canales-Rodríguez, Erick J.
Caseras, Xavier
Chaim-Avancini, Tiffany Moukbel
Ching, Christopher R. K.
Dannlowski, Udo
Deppe, Michael
Eyler, Lisa T.
Fatjo-Vilas, Mar
Foley, Sonya F.
Grotegerd, Dominik
Hajek, Tomas
Haukvik, Unn K.
Howells, Fleur M.
Jahanshad, Neda
Kugel, Harald
Lagerberg, Trine V.
Lawrie, Stephen M.
Linke, Julia O.
McIntosh, Andrew
Melloni, Elisa M. T.
Mitchell, Philip B.
Polosan, Mircea
Pomarol-Clotet, Edith
Repple, Jonathan
Roberts, Gloria
Roos, Annerine
Rosa, Pedro G. P.
Salvador, Raymond
Sarró, Salvador
Schofield, Peter R.
Serpa, Mauricio H.
Sim, Kang
Stein, Dan J.
Sussmann, Jess E.
Temmingh, Henk S.
Thompson, Paul M.
Verdolini, Norma
Vieta, Eduard
Wessa, Michele
Whalley, Heather C.
Zanetti, Marcus V.
Leboyer, Marion
Mangin, Jean-François
Henry, Chantal
Duchesnay, Edouard
Houenou, Josselin
author_facet Favre, Pauline
Pauling, Melissa
Stout, Jacques
Hozer, Franz
Sarrazin, Samuel
Abé, Christoph
Alda, Martin
Alloza, Clara
Alonso-Lana, Silvia
Andreassen, Ole A.
Baune, Bernhard T.
Benedetti, Francesco
Busatto, Geraldo F.
Canales-Rodríguez, Erick J.
Caseras, Xavier
Chaim-Avancini, Tiffany Moukbel
Ching, Christopher R. K.
Dannlowski, Udo
Deppe, Michael
Eyler, Lisa T.
Fatjo-Vilas, Mar
Foley, Sonya F.
Grotegerd, Dominik
Hajek, Tomas
Haukvik, Unn K.
Howells, Fleur M.
Jahanshad, Neda
Kugel, Harald
Lagerberg, Trine V.
Lawrie, Stephen M.
Linke, Julia O.
McIntosh, Andrew
Melloni, Elisa M. T.
Mitchell, Philip B.
Polosan, Mircea
Pomarol-Clotet, Edith
Repple, Jonathan
Roberts, Gloria
Roos, Annerine
Rosa, Pedro G. P.
Salvador, Raymond
Sarró, Salvador
Schofield, Peter R.
Serpa, Mauricio H.
Sim, Kang
Stein, Dan J.
Sussmann, Jess E.
Temmingh, Henk S.
Thompson, Paul M.
Verdolini, Norma
Vieta, Eduard
Wessa, Michele
Whalley, Heather C.
Zanetti, Marcus V.
Leboyer, Marion
Mangin, Jean-François
Henry, Chantal
Duchesnay, Edouard
Houenou, Josselin
author_sort Favre, Pauline
collection PubMed
description Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies have reported heterogeneous results and it is not clear how the clinical heterogeneity is related to the observed differences. This study aimed to identify WM abnormalities that differentiate patients with BD from healthy controls (HC) in the largest DTI dataset of patients with BD to date, collected via the ENIGMA network. We gathered individual tensor-derived regional metrics from 26 cohorts leading to a sample size of N = 3033 (1482 BD and 1551 HC). Mean fractional anisotropy (FA) from 43 regions of interest (ROI) and average whole-brain FA were entered into univariate mega- and meta-analyses to differentiate patients with BD from HC. Mega-analysis revealed significantly lower FA in patients with BD compared with HC in 29 regions, with the highest effect sizes observed within the corpus callosum (R(2) = 0.041, P(corr) < 0.001) and cingulum (right: R(2) = 0.041, left: R(2) = 0.040, P(corr) < 0.001). Lithium medication, later onset and short disease duration were related to higher FA along multiple ROIs. Results of the meta-analysis showed similar effects. We demonstrated widespread WM abnormalities in BD and highlighted that altered WM connectivity within the corpus callosum and the cingulum are strongly associated with BD. These brain abnormalities could represent a biomarker for use in the diagnosis of BD. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org.
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spelling pubmed-68983712019-12-09 Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals Favre, Pauline Pauling, Melissa Stout, Jacques Hozer, Franz Sarrazin, Samuel Abé, Christoph Alda, Martin Alloza, Clara Alonso-Lana, Silvia Andreassen, Ole A. Baune, Bernhard T. Benedetti, Francesco Busatto, Geraldo F. Canales-Rodríguez, Erick J. Caseras, Xavier Chaim-Avancini, Tiffany Moukbel Ching, Christopher R. K. Dannlowski, Udo Deppe, Michael Eyler, Lisa T. Fatjo-Vilas, Mar Foley, Sonya F. Grotegerd, Dominik Hajek, Tomas Haukvik, Unn K. Howells, Fleur M. Jahanshad, Neda Kugel, Harald Lagerberg, Trine V. Lawrie, Stephen M. Linke, Julia O. McIntosh, Andrew Melloni, Elisa M. T. Mitchell, Philip B. Polosan, Mircea Pomarol-Clotet, Edith Repple, Jonathan Roberts, Gloria Roos, Annerine Rosa, Pedro G. P. Salvador, Raymond Sarró, Salvador Schofield, Peter R. Serpa, Mauricio H. Sim, Kang Stein, Dan J. Sussmann, Jess E. Temmingh, Henk S. Thompson, Paul M. Verdolini, Norma Vieta, Eduard Wessa, Michele Whalley, Heather C. Zanetti, Marcus V. Leboyer, Marion Mangin, Jean-François Henry, Chantal Duchesnay, Edouard Houenou, Josselin Neuropsychopharmacology Article Fronto-limbic white matter (WM) abnormalities are assumed to lie at the heart of the pathophysiology of bipolar disorder (BD); however, diffusion tensor imaging (DTI) studies have reported heterogeneous results and it is not clear how the clinical heterogeneity is related to the observed differences. This study aimed to identify WM abnormalities that differentiate patients with BD from healthy controls (HC) in the largest DTI dataset of patients with BD to date, collected via the ENIGMA network. We gathered individual tensor-derived regional metrics from 26 cohorts leading to a sample size of N = 3033 (1482 BD and 1551 HC). Mean fractional anisotropy (FA) from 43 regions of interest (ROI) and average whole-brain FA were entered into univariate mega- and meta-analyses to differentiate patients with BD from HC. Mega-analysis revealed significantly lower FA in patients with BD compared with HC in 29 regions, with the highest effect sizes observed within the corpus callosum (R(2) = 0.041, P(corr) < 0.001) and cingulum (right: R(2) = 0.041, left: R(2) = 0.040, P(corr) < 0.001). Lithium medication, later onset and short disease duration were related to higher FA along multiple ROIs. Results of the meta-analysis showed similar effects. We demonstrated widespread WM abnormalities in BD and highlighted that altered WM connectivity within the corpus callosum and the cingulum are strongly associated with BD. These brain abnormalities could represent a biomarker for use in the diagnosis of BD. Interactive three-dimensional visualization of the results is available at www.enigma-viewer.org. Springer International Publishing 2019-08-21 2019-12 /pmc/articles/PMC6898371/ /pubmed/31434102 http://dx.doi.org/10.1038/s41386-019-0485-6 Text en © The Author(s), under exclusive licence to American College of Neuropsychopharmacology 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Favre, Pauline
Pauling, Melissa
Stout, Jacques
Hozer, Franz
Sarrazin, Samuel
Abé, Christoph
Alda, Martin
Alloza, Clara
Alonso-Lana, Silvia
Andreassen, Ole A.
Baune, Bernhard T.
Benedetti, Francesco
Busatto, Geraldo F.
Canales-Rodríguez, Erick J.
Caseras, Xavier
Chaim-Avancini, Tiffany Moukbel
Ching, Christopher R. K.
Dannlowski, Udo
Deppe, Michael
Eyler, Lisa T.
Fatjo-Vilas, Mar
Foley, Sonya F.
Grotegerd, Dominik
Hajek, Tomas
Haukvik, Unn K.
Howells, Fleur M.
Jahanshad, Neda
Kugel, Harald
Lagerberg, Trine V.
Lawrie, Stephen M.
Linke, Julia O.
McIntosh, Andrew
Melloni, Elisa M. T.
Mitchell, Philip B.
Polosan, Mircea
Pomarol-Clotet, Edith
Repple, Jonathan
Roberts, Gloria
Roos, Annerine
Rosa, Pedro G. P.
Salvador, Raymond
Sarró, Salvador
Schofield, Peter R.
Serpa, Mauricio H.
Sim, Kang
Stein, Dan J.
Sussmann, Jess E.
Temmingh, Henk S.
Thompson, Paul M.
Verdolini, Norma
Vieta, Eduard
Wessa, Michele
Whalley, Heather C.
Zanetti, Marcus V.
Leboyer, Marion
Mangin, Jean-François
Henry, Chantal
Duchesnay, Edouard
Houenou, Josselin
Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals
title Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals
title_full Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals
title_fullStr Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals
title_full_unstemmed Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals
title_short Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals
title_sort widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898371/
https://www.ncbi.nlm.nih.gov/pubmed/31434102
http://dx.doi.org/10.1038/s41386-019-0485-6
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