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The extent of complex fractionated atrial electrograms in the left atrium reflects age‐related electrical remodeling in patients with persistent atrial fibrillation

BACKGROUNDS: Alterations in the atrial structure and function associated with aging result in electric remodeling of the left atrium (LA) in patients with persistent atrial fibrillation (AF). We performed this study to evaluate the influence of age on electric remodeling as assessed by the extent of...

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Autores principales: Park, Yae Min, Lee, Dae In, Park, Hwan Cheol, Shim, Jaemin, Choi, Jong‐Il, Park, Sang Weon, Kim, Young‐Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898536/
https://www.ncbi.nlm.nih.gov/pubmed/31844470
http://dx.doi.org/10.1002/joa3.12248
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author Park, Yae Min
Lee, Dae In
Park, Hwan Cheol
Shim, Jaemin
Choi, Jong‐Il
Park, Sang Weon
Kim, Young‐Hoon
author_facet Park, Yae Min
Lee, Dae In
Park, Hwan Cheol
Shim, Jaemin
Choi, Jong‐Il
Park, Sang Weon
Kim, Young‐Hoon
author_sort Park, Yae Min
collection PubMed
description BACKGROUNDS: Alterations in the atrial structure and function associated with aging result in electric remodeling of the left atrium (LA) in patients with persistent atrial fibrillation (AF). We performed this study to evaluate the influence of age on electric remodeling as assessed by the extent of complex fractionated atrial electrograms (CFAEs) in the LA. METHODS: A total of 122 patients (mean age, 55.9 ± 10.4 years; range, 31‐79; 106 males) who underwent catheter ablation for drug‐refractory persistent AF were included in the study. The extent of CFAE was measured by CFAE area and its index (CFAE area/LA surface area × 100) using three‐dimensional automated software of NavX system. RESULTS: The mean value of CFAE extent was significantly different among age groups; the CFAE area decreased significantly with increasing age (30 seconds [43.2 ± 14.5 mm(2)] vs 40 seconds [28.6 ± 6.0 mm(2)] vs 50 seconds [22.8 ± 3.4 mm(2)] vs 60 seconds [15.3 ± 2.6 mm(2)] vs 70 seconds [10.3 ± 3.2 mm(2)]; P = .010). A similar significant decrease was observed in the CFAE area index (30 seconds [22.9 ± 7.4] vs 40 seconds [14.9 ± 3.4] vs 50 seconds [10.4 ± 1.6] vs 60 seconds [6.9 ± 1.2] vs 70 seconds [4.6 ± 1.4]; P = .002). Age had a significantly negative correlation with the CFAE area (r = −0.322, P < .001) and CFAE area index (r = −0.357, P < .001). CONCLUSIONS: Increasing age is associated with electric remodeling in the LA characterized by a decrease in the extent of CFAE area and its index.
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spelling pubmed-68985362019-12-16 The extent of complex fractionated atrial electrograms in the left atrium reflects age‐related electrical remodeling in patients with persistent atrial fibrillation Park, Yae Min Lee, Dae In Park, Hwan Cheol Shim, Jaemin Choi, Jong‐Il Park, Sang Weon Kim, Young‐Hoon J Arrhythm Original Article BACKGROUNDS: Alterations in the atrial structure and function associated with aging result in electric remodeling of the left atrium (LA) in patients with persistent atrial fibrillation (AF). We performed this study to evaluate the influence of age on electric remodeling as assessed by the extent of complex fractionated atrial electrograms (CFAEs) in the LA. METHODS: A total of 122 patients (mean age, 55.9 ± 10.4 years; range, 31‐79; 106 males) who underwent catheter ablation for drug‐refractory persistent AF were included in the study. The extent of CFAE was measured by CFAE area and its index (CFAE area/LA surface area × 100) using three‐dimensional automated software of NavX system. RESULTS: The mean value of CFAE extent was significantly different among age groups; the CFAE area decreased significantly with increasing age (30 seconds [43.2 ± 14.5 mm(2)] vs 40 seconds [28.6 ± 6.0 mm(2)] vs 50 seconds [22.8 ± 3.4 mm(2)] vs 60 seconds [15.3 ± 2.6 mm(2)] vs 70 seconds [10.3 ± 3.2 mm(2)]; P = .010). A similar significant decrease was observed in the CFAE area index (30 seconds [22.9 ± 7.4] vs 40 seconds [14.9 ± 3.4] vs 50 seconds [10.4 ± 1.6] vs 60 seconds [6.9 ± 1.2] vs 70 seconds [4.6 ± 1.4]; P = .002). Age had a significantly negative correlation with the CFAE area (r = −0.322, P < .001) and CFAE area index (r = −0.357, P < .001). CONCLUSIONS: Increasing age is associated with electric remodeling in the LA characterized by a decrease in the extent of CFAE area and its index. John Wiley and Sons Inc. 2019-10-17 /pmc/articles/PMC6898536/ /pubmed/31844470 http://dx.doi.org/10.1002/joa3.12248 Text en © 2019 The Authors. Journal of Arrhythmia published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Heart Rhythm Society. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Article
Park, Yae Min
Lee, Dae In
Park, Hwan Cheol
Shim, Jaemin
Choi, Jong‐Il
Park, Sang Weon
Kim, Young‐Hoon
The extent of complex fractionated atrial electrograms in the left atrium reflects age‐related electrical remodeling in patients with persistent atrial fibrillation
title The extent of complex fractionated atrial electrograms in the left atrium reflects age‐related electrical remodeling in patients with persistent atrial fibrillation
title_full The extent of complex fractionated atrial electrograms in the left atrium reflects age‐related electrical remodeling in patients with persistent atrial fibrillation
title_fullStr The extent of complex fractionated atrial electrograms in the left atrium reflects age‐related electrical remodeling in patients with persistent atrial fibrillation
title_full_unstemmed The extent of complex fractionated atrial electrograms in the left atrium reflects age‐related electrical remodeling in patients with persistent atrial fibrillation
title_short The extent of complex fractionated atrial electrograms in the left atrium reflects age‐related electrical remodeling in patients with persistent atrial fibrillation
title_sort extent of complex fractionated atrial electrograms in the left atrium reflects age‐related electrical remodeling in patients with persistent atrial fibrillation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898536/
https://www.ncbi.nlm.nih.gov/pubmed/31844470
http://dx.doi.org/10.1002/joa3.12248
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