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Serum levels of gamma-glutamyltransferase predict outcome in heart failure with preserved ejection fraction
Previous studies suggested an association between heart failure (HF) and hepatic disorders. Liver function parameters have been shown to predict outcome in HF with reduced ejection fraction, but their impact in HF with preserved ejection fraction (HFpEF) has not yet been investigated. Between Januar...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898583/ https://www.ncbi.nlm.nih.gov/pubmed/31811258 http://dx.doi.org/10.1038/s41598-019-55116-8 |
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author | Dalos, Daniel Binder, Christina Duca, Franz Aschauer, Stefan Kammerlander, Andreas Hengstenberg, Christian Mascherbauer, Julia Reiberger, Thomas Bonderman, Diana |
author_facet | Dalos, Daniel Binder, Christina Duca, Franz Aschauer, Stefan Kammerlander, Andreas Hengstenberg, Christian Mascherbauer, Julia Reiberger, Thomas Bonderman, Diana |
author_sort | Dalos, Daniel |
collection | PubMed |
description | Previous studies suggested an association between heart failure (HF) and hepatic disorders. Liver function parameters have been shown to predict outcome in HF with reduced ejection fraction, but their impact in HF with preserved ejection fraction (HFpEF) has not yet been investigated. Between January 2011 and February 2017, 274 patients with confirmed HFpEF were enrolled (age 71.3 ± 8.4 years, 69.3% female) in a prospective registry. During a median follow-up of 21.5 ± 18.6 months, 97 patients (35.4%) reached the combined endpoint defined as hospitalization due to HF and/ or death from any cause. By multivariable cox regression, serum gamma-glutamyltransferase (GT) was independently associated with outcome (Hazard Ratio (HR) 1.002, p = 0.004) along with N-terminal pro brain natriuretic peptide (HR 2.213, p = 0.001) and hemoglobin (HR 0.840, p = 0.006). Kaplan-Meier analysis showed that patients with serum gamma-GT levels above a median of 36 U/L had significantly more events as compared to the remainder of the group (log-rank p = 0.012). By multivariable logistic regression, higher early mitral inflow velocity/ mitral peak velocity of late filling (Odds Ratio (OR) 2.173, p = 0.024), higher right atrial (RA) pressure (OR 1.139, p < 0.001) and larger RA diameter (OR 1.070, p = 0.001) were independently associated with serum gamma-GT > 36 U/L. Serum levels of gamma-GT are associated with both left and right-sided cardiac alterations and may serve as a simple tool for risk prediction in HFpEF, especially when further diagnostic modalities are not available. |
format | Online Article Text |
id | pubmed-6898583 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-68985832019-12-12 Serum levels of gamma-glutamyltransferase predict outcome in heart failure with preserved ejection fraction Dalos, Daniel Binder, Christina Duca, Franz Aschauer, Stefan Kammerlander, Andreas Hengstenberg, Christian Mascherbauer, Julia Reiberger, Thomas Bonderman, Diana Sci Rep Article Previous studies suggested an association between heart failure (HF) and hepatic disorders. Liver function parameters have been shown to predict outcome in HF with reduced ejection fraction, but their impact in HF with preserved ejection fraction (HFpEF) has not yet been investigated. Between January 2011 and February 2017, 274 patients with confirmed HFpEF were enrolled (age 71.3 ± 8.4 years, 69.3% female) in a prospective registry. During a median follow-up of 21.5 ± 18.6 months, 97 patients (35.4%) reached the combined endpoint defined as hospitalization due to HF and/ or death from any cause. By multivariable cox regression, serum gamma-glutamyltransferase (GT) was independently associated with outcome (Hazard Ratio (HR) 1.002, p = 0.004) along with N-terminal pro brain natriuretic peptide (HR 2.213, p = 0.001) and hemoglobin (HR 0.840, p = 0.006). Kaplan-Meier analysis showed that patients with serum gamma-GT levels above a median of 36 U/L had significantly more events as compared to the remainder of the group (log-rank p = 0.012). By multivariable logistic regression, higher early mitral inflow velocity/ mitral peak velocity of late filling (Odds Ratio (OR) 2.173, p = 0.024), higher right atrial (RA) pressure (OR 1.139, p < 0.001) and larger RA diameter (OR 1.070, p = 0.001) were independently associated with serum gamma-GT > 36 U/L. Serum levels of gamma-GT are associated with both left and right-sided cardiac alterations and may serve as a simple tool for risk prediction in HFpEF, especially when further diagnostic modalities are not available. Nature Publishing Group UK 2019-12-06 /pmc/articles/PMC6898583/ /pubmed/31811258 http://dx.doi.org/10.1038/s41598-019-55116-8 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Dalos, Daniel Binder, Christina Duca, Franz Aschauer, Stefan Kammerlander, Andreas Hengstenberg, Christian Mascherbauer, Julia Reiberger, Thomas Bonderman, Diana Serum levels of gamma-glutamyltransferase predict outcome in heart failure with preserved ejection fraction |
title | Serum levels of gamma-glutamyltransferase predict outcome in heart failure with preserved ejection fraction |
title_full | Serum levels of gamma-glutamyltransferase predict outcome in heart failure with preserved ejection fraction |
title_fullStr | Serum levels of gamma-glutamyltransferase predict outcome in heart failure with preserved ejection fraction |
title_full_unstemmed | Serum levels of gamma-glutamyltransferase predict outcome in heart failure with preserved ejection fraction |
title_short | Serum levels of gamma-glutamyltransferase predict outcome in heart failure with preserved ejection fraction |
title_sort | serum levels of gamma-glutamyltransferase predict outcome in heart failure with preserved ejection fraction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898583/ https://www.ncbi.nlm.nih.gov/pubmed/31811258 http://dx.doi.org/10.1038/s41598-019-55116-8 |
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