Essential role of the initial activation signal in isotype selection upon deletion of a transcriptionally committed promoter

Class switch recombination (CSR), which targets exclusively the constant region of the immunoglobulin heavy chain (IgH) locus, plays an important role in humoral immunity by generating different antibody effector functions. The IgH constant locus contains multiple genes controlled by isotype (I) pro...

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Detalles Bibliográficos
Autores principales: Santos, Joana M., Oudinet, Chloé, Schöne, Lisa, Dauba, Audrey, Khamlichi, Ahmed Amine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898632/
https://www.ncbi.nlm.nih.gov/pubmed/31811188
http://dx.doi.org/10.1038/s41598-019-54929-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898632/
https://www.ncbi.nlm.nih.gov/pubmed/31811188
http://dx.doi.org/10.1038/s41598-019-54929-x

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