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Essential role of the initial activation signal in isotype selection upon deletion of a transcriptionally committed promoter
Class switch recombination (CSR), which targets exclusively the constant region of the immunoglobulin heavy chain (IgH) locus, plays an important role in humoral immunity by generating different antibody effector functions. The IgH constant locus contains multiple genes controlled by isotype (I) pro...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898632/ https://www.ncbi.nlm.nih.gov/pubmed/31811188 http://dx.doi.org/10.1038/s41598-019-54929-x |