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Prevalence and Impact of Treatment Crossover in Cardiac Surgery Randomized Trials: A Meta‐Epidemiologic Study

BACKGROUND: Crossover dilutes treatment effect and reduces statistical power of intention‐to‐treat analysis. We examined incidence and impact on cardiac surgery randomized controlled trial (RCT) outcomes of crossover from experimental to control interventions, or vice versa. METHODS AND RESULTS: MED...

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Detalles Bibliográficos
Autores principales:	Gaudino, Mario, Fremes, Stephen E., Ruel, Marc, Di Franco, Antonino, Di Mauro, Michele, Chikwe, Joanna, Frati, Giacomo, Girardi, Leonard N., Taggart, David P., Biondi‐Zoccai, Giuseppe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Systematic Review and Meta‐analysis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898839/ https://www.ncbi.nlm.nih.gov/pubmed/31663420 http://dx.doi.org/10.1161/JAHA.119.013711

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