N(6)-methyladenosine (m(6)A) RNA modification in gastrointestinal tract cancers: roles, mechanisms, and applications

Analogous to DNA methylation and histone modification, RNA modification, as another epigenetic layer, plays an important role in many diseases, especially in tumours. As the most common form of RNA modification, m(6)A methylation has attracted increasing research interest in recent years. m(6)A is c...

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Detalles Bibliográficos
Autores principales: Hu, Bin-bin, Wang, Xiao-yan, Gu, Xu-Yu, Zou, Chen, Gao, Zhen-jun, Zhang, Heng, Fan, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898962/
https://www.ncbi.nlm.nih.gov/pubmed/31810483
http://dx.doi.org/10.1186/s12943-019-1099-7
Descripción
Sumario:Analogous to DNA methylation and histone modification, RNA modification, as another epigenetic layer, plays an important role in many diseases, especially in tumours. As the most common form of RNA modification, m(6)A methylation has attracted increasing research interest in recent years. m(6)A is catalysed by RNA methyltransferases METTL3, METTL14 and WTAP (writers), m(6)A is removed by the demethylases FTO and ALKBH5 (erasers) and interacts with m6A-binding proteins, such as YT521-B homology (YTH) domain-containing proteins. This article reviews recent studies on methylation modification of m(6)A in gastrointestinal tract cancers.

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