N(6)-methyladenosine (m(6)A) RNA modification in gastrointestinal tract cancers: roles, mechanisms, and applications

Analogous to DNA methylation and histone modification, RNA modification, as another epigenetic layer, plays an important role in many diseases, especially in tumours. As the most common form of RNA modification, m(6)A methylation has attracted increasing research interest in recent years. m(6)A is c...

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Autores principales: Hu, Bin-bin, Wang, Xiao-yan, Gu, Xu-Yu, Zou, Chen, Gao, Zhen-jun, Zhang, Heng, Fan, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898962/
https://www.ncbi.nlm.nih.gov/pubmed/31810483
http://dx.doi.org/10.1186/s12943-019-1099-7
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author Hu, Bin-bin
Wang, Xiao-yan
Gu, Xu-Yu
Zou, Chen
Gao, Zhen-jun
Zhang, Heng
Fan, Yu
author_facet Hu, Bin-bin
Wang, Xiao-yan
Gu, Xu-Yu
Zou, Chen
Gao, Zhen-jun
Zhang, Heng
Fan, Yu
author_sort Hu, Bin-bin
collection PubMed
description Analogous to DNA methylation and histone modification, RNA modification, as another epigenetic layer, plays an important role in many diseases, especially in tumours. As the most common form of RNA modification, m(6)A methylation has attracted increasing research interest in recent years. m(6)A is catalysed by RNA methyltransferases METTL3, METTL14 and WTAP (writers), m(6)A is removed by the demethylases FTO and ALKBH5 (erasers) and interacts with m6A-binding proteins, such as YT521-B homology (YTH) domain-containing proteins. This article reviews recent studies on methylation modification of m(6)A in gastrointestinal tract cancers.
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spelling pubmed-68989622019-12-11 N(6)-methyladenosine (m(6)A) RNA modification in gastrointestinal tract cancers: roles, mechanisms, and applications Hu, Bin-bin Wang, Xiao-yan Gu, Xu-Yu Zou, Chen Gao, Zhen-jun Zhang, Heng Fan, Yu Mol Cancer Review Analogous to DNA methylation and histone modification, RNA modification, as another epigenetic layer, plays an important role in many diseases, especially in tumours. As the most common form of RNA modification, m(6)A methylation has attracted increasing research interest in recent years. m(6)A is catalysed by RNA methyltransferases METTL3, METTL14 and WTAP (writers), m(6)A is removed by the demethylases FTO and ALKBH5 (erasers) and interacts with m6A-binding proteins, such as YT521-B homology (YTH) domain-containing proteins. This article reviews recent studies on methylation modification of m(6)A in gastrointestinal tract cancers. BioMed Central 2019-12-07 /pmc/articles/PMC6898962/ /pubmed/31810483 http://dx.doi.org/10.1186/s12943-019-1099-7 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Hu, Bin-bin
Wang, Xiao-yan
Gu, Xu-Yu
Zou, Chen
Gao, Zhen-jun
Zhang, Heng
Fan, Yu
N(6)-methyladenosine (m(6)A) RNA modification in gastrointestinal tract cancers: roles, mechanisms, and applications
title N(6)-methyladenosine (m(6)A) RNA modification in gastrointestinal tract cancers: roles, mechanisms, and applications
title_full N(6)-methyladenosine (m(6)A) RNA modification in gastrointestinal tract cancers: roles, mechanisms, and applications
title_fullStr N(6)-methyladenosine (m(6)A) RNA modification in gastrointestinal tract cancers: roles, mechanisms, and applications
title_full_unstemmed N(6)-methyladenosine (m(6)A) RNA modification in gastrointestinal tract cancers: roles, mechanisms, and applications
title_short N(6)-methyladenosine (m(6)A) RNA modification in gastrointestinal tract cancers: roles, mechanisms, and applications
title_sort n(6)-methyladenosine (m(6)a) rna modification in gastrointestinal tract cancers: roles, mechanisms, and applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898962/
https://www.ncbi.nlm.nih.gov/pubmed/31810483
http://dx.doi.org/10.1186/s12943-019-1099-7
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