Cargando…

DDX56 inhibits type I interferon by disrupting assembly of IRF3–IPO5 to inhibit IRF3 nucleus import

Transcription factor IRF3-mediated type I interferon induction plays a role in antiviral innate immunity. However, mechanisms for the control and regulation of IRF3 nuclear import remain largely unknown. We have identified DEAD box polypeptide 56 (DDX56) as a negative regulator of virus-triggered IF...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Dan, Fu, Shaozu, Wu, Zhengqian, Yang, Wenping, Ru, Yi, Shu, Hongbing, Liu, Xiangtao, Zheng, Haixue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899003/ https://www.ncbi.nlm.nih.gov/pubmed/31340999 http://dx.doi.org/10.1242/jcs.230409

Ejemplares similares

Correction: DDX56 inhibits type I interferon by disrupting assembly of IRF3–IPO5 to inhibit IRF3 nucleus import
por: Li, Dan, et al.
Publicado: (2020)

PLAAT1 inhibits type I interferon response via degradation of IRF3 and IRF7 in Zebrafish
por: Zhao, Xin, et al.
Publicado: (2022)

Reovirus inhibits interferon production by sequestering IRF3 into viral factories
por: Stanifer, Megan L., et al.
Publicado: (2017)

Peste des Petits Ruminants Virus Nucleocapsid Protein Inhibits Beta Interferon Production by Interacting with IRF3 To Block Its Activation
por: Zhu, Zixiang, et al.
Publicado: (2019)

DDX50 Is a Viral Restriction Factor That Enhances IRF3 Activation
por: Pallett, Mitchell A., et al.
Publicado: (2022)

MAPK phosphatase 5 inhibits IRF3
por: Png, Chin Wen, et al.
Publicado: (2015)

G3BP1 inhibits RNA virus replication by positively regulating RIG-I-mediated cellular antiviral response
por: Yang, Wenping, et al.
Publicado: (2019)

TANK-Binding Kinase 1 (TBK1) Isoforms Negatively Regulate Type I Interferon Induction by Inhibiting TBK1-IRF3 Interaction and IRF3 Phosphorylation
por: Hu, Yi Wei, et al.
Publicado: (2018)

Grass carp reovirus VP56 represses interferon production by degrading phosphorylated IRF7
por: Zhang, Can, et al.
Publicado: (2020)

Interferon Regulatory Factor (Irf)-1 and Irf-2 Regulate Interferon γ–Dependent Cyclooxygenase 2 Expression
por: Blanco, Jorge C. G., et al.
Publicado: (2000)

IRF3 and IRF7 mediate neovascularization via inflammatory cytokines
por: Simons, Karin H., et al.
Publicado: (2019)

Grass Carp (Ctenopharyngodon idella) KAT8 Inhibits IFN 1 Response Through Acetylating IRF3/IRF7
por: Li, Meifeng, et al.
Publicado: (2022)

IFITM3 inhibits virus-triggered induction of type I interferon by mediating autophagosome-dependent degradation of IRF3
por: Jiang, Li-Qun, et al.
Publicado: (2017)

DNA-binding landscape of IRF3, IRF5 and IRF7 dimers: implications for dimer-specific gene regulation
por: Andrilenas, Kellen K, et al.
Publicado: (2018)

HSPD1 Interacts with IRF3 to Facilitate Interferon-Beta Induction
por: Lin, Lan, et al.
Publicado: (2014)

ERRα negatively regulates type I interferon induction by inhibiting TBK1-IRF3 interaction
por: He, Xiang, et al.
Publicado: (2017)

KAT8 selectively inhibits antiviral immunity by acetylating IRF3
por: Huai, Wanwan, et al.
Publicado: (2019)

Inhibition of IRF3-dependent antiviral responses by cellular and viral proteins
por: Tsuchida, Tetsuo, et al.
Publicado: (2009)

HIST1H1C Regulates Interferon-β and Inhibits Influenza Virus Replication by Interacting with IRF3
por: Liu, Xiaokun, et al.
Publicado: (2017)

Interferon regulatory factor (IRF) 3 is critical for the development of experimental autoimmune encephalomyelitis
por: Fitzgerald, Denise C, et al.
Publicado: (2014)

Induction of Interferon-Stimulated Genes by IRF3 Promotes Replication of Toxoplasma gondii
por: Majumdar, Tanmay, et al.
Publicado: (2015)

Interferon gamma inhibits transmissible gastroenteritis virus infection mediated by an IRF1 signaling pathway
por: Shan, Lingling, et al.
Publicado: (2019)

Correction: KAT8 selectively inhibits antiviral immunity by acetylating IRF3
por: Huai, Wanwan, et al.
Publicado: (2019)

RNF138 Downregulates Antiviral Innate Immunity by Inhibiting IRF3 Activation
por: Zeng, Xianhuang, et al.
Publicado: (2023)

Phosphorylation of interferon regulatory factor 9 (IRF9)
por: Paul, Alvin, et al.
Publicado: (2023)

IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling
por: Lazear, Helen M., et al.
Publicado: (2013)

Opposing Roles for Interferon Regulatory Factor-3 (IRF-3) and Type I Interferon Signaling during Plague
por: Patel, Ami A., et al.
Publicado: (2012)

IRF3 balances killing and cleaning
por: Williams, Ruth
Publicado: (2006)

Cooperative contributions of Interferon regulatory factor 1 (IRF1) and IRF8 to interferon-γ-mediated cytotoxic effects on oligodendroglial progenitor cells
por: Horiuchi, Makoto, et al.
Publicado: (2011)

SCD2-mediated cooperative activation of IRF3-IRF9 regulatory circuit controls type I interferon transcriptome in CD4(+) T cells
por: Kanno, Toshio, et al.
Publicado: (2022)

Characterization of distinct molecular interactions responsible for IRF3 and IRF7 phosphorylation and subsequent dimerization
por: Dalskov, Louise, et al.
Publicado: (2020)

NSD3 keeps IRF3 active
por: Mino, Takashi, et al.
Publicado: (2017)

Interferon Regulatory Factors IRF1 and IRF7 Directly Regulate Gene Expression in Bats in Response to Viral Infection
por: Irving, Aaron T., et al.
Publicado: (2020)

Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7
por: Unterholzner, Leonie, et al.
Publicado: (2011)

Correction: IRF-3, IRF-5, and IRF-7 Coordinately Regulate the Type I IFN Response in Myeloid Dendritic Cells Downstream of MAVS Signaling
por: Lazear, Helen M., et al.
Publicado: (2013)

SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation
por: Wang, Wenjing, et al.
Publicado: (2021)

The RNA helicase DDX3 promotes IFNB transcription via enhancing IRF-3/p300 holocomplex binding to the IFNB promoter
por: Saikruang, Wilaiporn, et al.
Publicado: (2022)

Irf3 Polymorphism Alters Induction of Interferon Beta in Response to Listeria monocytogenes Infection
por: Garifulin, Oleg, et al.
Publicado: (2007)

Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon β
por: Bakshi, Siddharth, et al.
Publicado: (2017)

IRF3 and Type I Interferons Fuel a Fatal Response to Myocardial Infarction
por: King, Kevin R., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_nbhgrkbj3uc8s4si0ug38kljvn