Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility

In breast cancer, the increased stiffness of the extracellular matrix (ECM) is a key driver of malignancy. Yet little is known about the epigenomic changes that underlie the tumorigenic impact of ECM mechanics. Here, we show in a 3D culture model of breast cancer that stiff ECM induces a tumorigenic...

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Detalles Bibliográficos
Autores principales: Stowers, Ryan S., Shcherbina, Anna, Israeli, Johnny, Gruber, Joshua J., Chang, Julie, Nam, Sungmin, Rabiee, Atefeh, Teruel, Mary N., Snyder, Michael P., Kundaje, Anshul, Chaudhuri, Ovijit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899165/
https://www.ncbi.nlm.nih.gov/pubmed/31285581
http://dx.doi.org/10.1038/s41551-019-0420-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899165/
https://www.ncbi.nlm.nih.gov/pubmed/31285581
http://dx.doi.org/10.1038/s41551-019-0420-5

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