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Matrix stiffness induces a tumorigenic phenotype in mammary epithelium through changes in chromatin accessibility
In breast cancer, the increased stiffness of the extracellular matrix (ECM) is a key driver of malignancy. Yet little is known about the epigenomic changes that underlie the tumorigenic impact of ECM mechanics. Here, we show in a 3D culture model of breast cancer that stiff ECM induces a tumorigenic...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899165/ https://www.ncbi.nlm.nih.gov/pubmed/31285581 http://dx.doi.org/10.1038/s41551-019-0420-5 |