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Pituitary gland volumes in patients with obsessive-compulsive disorder before and after cognitive-behavioral therapy

OBJECTIVE: The beneficial effects of psychopharmacological and cognitive behavioral therapy (CBT) on the brain are not well understood. In a previous study, we found smaller pituitary volumes in patients with obsessive-compulsive disorder (OCD). The purpose of this study was to examine the effect of...

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Autores principales: Atmaca, Murad, Yildirim, Hanefi, Yilmaz, Seda, Caglar, Neslihan, Baykara, Sema, Kekilli, Yasemin, Koseoglu, Filiz, Turkcapar, Hakan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Psiquiatria 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899379/
https://www.ncbi.nlm.nih.gov/pubmed/29898196
http://dx.doi.org/10.1590/1516-4446-2017-2449
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author Atmaca, Murad
Yildirim, Hanefi
Yilmaz, Seda
Caglar, Neslihan
Baykara, Sema
Kekilli, Yasemin
Koseoglu, Filiz
Turkcapar, Hakan
author_facet Atmaca, Murad
Yildirim, Hanefi
Yilmaz, Seda
Caglar, Neslihan
Baykara, Sema
Kekilli, Yasemin
Koseoglu, Filiz
Turkcapar, Hakan
author_sort Atmaca, Murad
collection PubMed
description OBJECTIVE: The beneficial effects of psychopharmacological and cognitive behavioral therapy (CBT) on the brain are not well understood. In a previous study, we found smaller pituitary volumes in patients with obsessive-compulsive disorder (OCD). The purpose of this study was to examine the effect of CBT on pituitary gland volume. METHODS: A total of 81 patients with various anxiety disorders and the same number of healthy controls underwent magnetic resonance imaging, and their pituitary gland volumes were compared at baseline. Pituitary gland volumes were also measured before and after CBT in the patient group. RESULTS: OCD patients had smaller pituitary gland volumes at baseline than healthy controls (0.54±0.29 cm(3) for OCD patients vs. 0.82±0.30 cm(3) for healthy controls; p < 0.001). We found no significant changes in OCD patient pituitary gland volume after the 16-week treatment period, with mean pre- and post-treatment values of 0.54±0.29 cm(3) and 0.56±0.32 cm(3), respectively (p > 0.05). CONCLUSION: Our results indicate an absence of post-CBT volumetric changes in the pituitary gland of OCD patients.
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spelling pubmed-68993792019-12-30 Pituitary gland volumes in patients with obsessive-compulsive disorder before and after cognitive-behavioral therapy Atmaca, Murad Yildirim, Hanefi Yilmaz, Seda Caglar, Neslihan Baykara, Sema Kekilli, Yasemin Koseoglu, Filiz Turkcapar, Hakan Braz J Psychiatry Original Article OBJECTIVE: The beneficial effects of psychopharmacological and cognitive behavioral therapy (CBT) on the brain are not well understood. In a previous study, we found smaller pituitary volumes in patients with obsessive-compulsive disorder (OCD). The purpose of this study was to examine the effect of CBT on pituitary gland volume. METHODS: A total of 81 patients with various anxiety disorders and the same number of healthy controls underwent magnetic resonance imaging, and their pituitary gland volumes were compared at baseline. Pituitary gland volumes were also measured before and after CBT in the patient group. RESULTS: OCD patients had smaller pituitary gland volumes at baseline than healthy controls (0.54±0.29 cm(3) for OCD patients vs. 0.82±0.30 cm(3) for healthy controls; p < 0.001). We found no significant changes in OCD patient pituitary gland volume after the 16-week treatment period, with mean pre- and post-treatment values of 0.54±0.29 cm(3) and 0.56±0.32 cm(3), respectively (p > 0.05). CONCLUSION: Our results indicate an absence of post-CBT volumetric changes in the pituitary gland of OCD patients. Associação Brasileira de Psiquiatria 2018-06-11 /pmc/articles/PMC6899379/ /pubmed/29898196 http://dx.doi.org/10.1590/1516-4446-2017-2449 Text en http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Atmaca, Murad
Yildirim, Hanefi
Yilmaz, Seda
Caglar, Neslihan
Baykara, Sema
Kekilli, Yasemin
Koseoglu, Filiz
Turkcapar, Hakan
Pituitary gland volumes in patients with obsessive-compulsive disorder before and after cognitive-behavioral therapy
title Pituitary gland volumes in patients with obsessive-compulsive disorder before and after cognitive-behavioral therapy
title_full Pituitary gland volumes in patients with obsessive-compulsive disorder before and after cognitive-behavioral therapy
title_fullStr Pituitary gland volumes in patients with obsessive-compulsive disorder before and after cognitive-behavioral therapy
title_full_unstemmed Pituitary gland volumes in patients with obsessive-compulsive disorder before and after cognitive-behavioral therapy
title_short Pituitary gland volumes in patients with obsessive-compulsive disorder before and after cognitive-behavioral therapy
title_sort pituitary gland volumes in patients with obsessive-compulsive disorder before and after cognitive-behavioral therapy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899379/
https://www.ncbi.nlm.nih.gov/pubmed/29898196
http://dx.doi.org/10.1590/1516-4446-2017-2449
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