Pregnant women with confirmed neoplasms should not have noninvasive prenatal testing

Incidental diagnoses of an occult maternal malignancy have been reported upon aberrant routine noninvasive prenatal testing (NIPT). The presence of tumor‐derived cell‐free DNA in the maternal circulation can skew the NIPT profile. Pregnant women with a confirmed neoplastic disease should not have NI...

Descripción completa

Detalles Bibliográficos
Autores principales: Lenaerts, Liesbeth, Van Calsteren, Kristel, Che, Huiwen, Vermeesch, Joris Robert, Amant, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899454/
https://www.ncbi.nlm.nih.gov/pubmed/31393011
http://dx.doi.org/10.1002/pd.5544
Descripción
Sumario:Incidental diagnoses of an occult maternal malignancy have been reported upon aberrant routine noninvasive prenatal testing (NIPT). The presence of tumor‐derived cell‐free DNA in the maternal circulation can skew the NIPT profile. Pregnant women with a confirmed neoplastic disease should not have NIPT testing for fetal aneuploidy screening since NIPT results cannot accurately be applied to assess the fetal chromosomal constitution in this condition.

Ejemplares similares