Pregnant women with confirmed neoplasms should not have noninvasive prenatal testing

Incidental diagnoses of an occult maternal malignancy have been reported upon aberrant routine noninvasive prenatal testing (NIPT). The presence of tumor‐derived cell‐free DNA in the maternal circulation can skew the NIPT profile. Pregnant women with a confirmed neoplastic disease should not have NI...

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Autores principales: Lenaerts, Liesbeth, Van Calsteren, Kristel, Che, Huiwen, Vermeesch, Joris Robert, Amant, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Letters
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899454/
https://www.ncbi.nlm.nih.gov/pubmed/31393011
http://dx.doi.org/10.1002/pd.5544
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author Lenaerts, Liesbeth
Van Calsteren, Kristel
Che, Huiwen
Vermeesch, Joris Robert
Amant, Frédéric
author_facet Lenaerts, Liesbeth
Van Calsteren, Kristel
Che, Huiwen
Vermeesch, Joris Robert
Amant, Frédéric
author_sort Lenaerts, Liesbeth
collection PubMed
description Incidental diagnoses of an occult maternal malignancy have been reported upon aberrant routine noninvasive prenatal testing (NIPT). The presence of tumor‐derived cell‐free DNA in the maternal circulation can skew the NIPT profile. Pregnant women with a confirmed neoplastic disease should not have NIPT testing for fetal aneuploidy screening since NIPT results cannot accurately be applied to assess the fetal chromosomal constitution in this condition.
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spelling pubmed-68994542019-12-19 Pregnant women with confirmed neoplasms should not have noninvasive prenatal testing Lenaerts, Liesbeth Van Calsteren, Kristel Che, Huiwen Vermeesch, Joris Robert Amant, Frédéric Prenat Diagn Research Letters Incidental diagnoses of an occult maternal malignancy have been reported upon aberrant routine noninvasive prenatal testing (NIPT). The presence of tumor‐derived cell‐free DNA in the maternal circulation can skew the NIPT profile. Pregnant women with a confirmed neoplastic disease should not have NIPT testing for fetal aneuploidy screening since NIPT results cannot accurately be applied to assess the fetal chromosomal constitution in this condition. John Wiley and Sons Inc. 2019-08-28 2019-11 /pmc/articles/PMC6899454/ /pubmed/31393011 http://dx.doi.org/10.1002/pd.5544 Text en © 2019 The Authors. Prenatal Diagnosis published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Letters
Lenaerts, Liesbeth
Van Calsteren, Kristel
Che, Huiwen
Vermeesch, Joris Robert
Amant, Frédéric
Pregnant women with confirmed neoplasms should not have noninvasive prenatal testing
title Pregnant women with confirmed neoplasms should not have noninvasive prenatal testing
title_full Pregnant women with confirmed neoplasms should not have noninvasive prenatal testing
title_fullStr Pregnant women with confirmed neoplasms should not have noninvasive prenatal testing
title_full_unstemmed Pregnant women with confirmed neoplasms should not have noninvasive prenatal testing
title_short Pregnant women with confirmed neoplasms should not have noninvasive prenatal testing
title_sort pregnant women with confirmed neoplasms should not have noninvasive prenatal testing
topic Research Letters
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899454/
https://www.ncbi.nlm.nih.gov/pubmed/31393011
http://dx.doi.org/10.1002/pd.5544
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