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Membrane-Associated Enteroviruses Undergo Intercellular Transmission as Pools of Sibling Viral Genomes

Some viruses are released from cells as pools of membrane-associated virions. By increasing the multiplicity of infection (MOI), this type of collective dispersal could favor viral cooperation, but also the emergence of cheater-like viruses such as defective interfering particles. To better understa...

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Detalles Bibliográficos
Autores principales: Bou, Juan-Vicente, Geller, Ron, Sanjuán, Rafael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899498/
https://www.ncbi.nlm.nih.gov/pubmed/31618638
http://dx.doi.org/10.1016/j.celrep.2019.09.014
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author Bou, Juan-Vicente
Geller, Ron
Sanjuán, Rafael
author_facet Bou, Juan-Vicente
Geller, Ron
Sanjuán, Rafael
author_sort Bou, Juan-Vicente
collection PubMed
description Some viruses are released from cells as pools of membrane-associated virions. By increasing the multiplicity of infection (MOI), this type of collective dispersal could favor viral cooperation, but also the emergence of cheater-like viruses such as defective interfering particles. To better understand this process, we examined the genetic diversity of membrane-associated coxsackievirus infectious units. We find that infected cells release membranous structures (including vesicles) that contain 8–21 infectious particles on average. However, in most cases (62%–93%), these structures do not promote the co-transmission of different viral genetic variants present in a cell. Furthermore, collective dispersal has no effect on viral population sequence diversity. Our results indicate that membrane-associated collective infectious units typically contain viral particles derived from the same parental genome. Hence, if cooperation occurs, it should probably involve sibling viral particles rather than different variants. As shown by social evolution theory, cooperation among siblings should be robust against cheater invasion.
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spelling pubmed-68994982020-01-21 Membrane-Associated Enteroviruses Undergo Intercellular Transmission as Pools of Sibling Viral Genomes Bou, Juan-Vicente Geller, Ron Sanjuán, Rafael Cell Rep Article Some viruses are released from cells as pools of membrane-associated virions. By increasing the multiplicity of infection (MOI), this type of collective dispersal could favor viral cooperation, but also the emergence of cheater-like viruses such as defective interfering particles. To better understand this process, we examined the genetic diversity of membrane-associated coxsackievirus infectious units. We find that infected cells release membranous structures (including vesicles) that contain 8–21 infectious particles on average. However, in most cases (62%–93%), these structures do not promote the co-transmission of different viral genetic variants present in a cell. Furthermore, collective dispersal has no effect on viral population sequence diversity. Our results indicate that membrane-associated collective infectious units typically contain viral particles derived from the same parental genome. Hence, if cooperation occurs, it should probably involve sibling viral particles rather than different variants. As shown by social evolution theory, cooperation among siblings should be robust against cheater invasion. Cell Press 2019-10-15 /pmc/articles/PMC6899498/ /pubmed/31618638 http://dx.doi.org/10.1016/j.celrep.2019.09.014 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Bou, Juan-Vicente
Geller, Ron
Sanjuán, Rafael
Membrane-Associated Enteroviruses Undergo Intercellular Transmission as Pools of Sibling Viral Genomes
title Membrane-Associated Enteroviruses Undergo Intercellular Transmission as Pools of Sibling Viral Genomes
title_full Membrane-Associated Enteroviruses Undergo Intercellular Transmission as Pools of Sibling Viral Genomes
title_fullStr Membrane-Associated Enteroviruses Undergo Intercellular Transmission as Pools of Sibling Viral Genomes
title_full_unstemmed Membrane-Associated Enteroviruses Undergo Intercellular Transmission as Pools of Sibling Viral Genomes
title_short Membrane-Associated Enteroviruses Undergo Intercellular Transmission as Pools of Sibling Viral Genomes
title_sort membrane-associated enteroviruses undergo intercellular transmission as pools of sibling viral genomes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899498/
https://www.ncbi.nlm.nih.gov/pubmed/31618638
http://dx.doi.org/10.1016/j.celrep.2019.09.014
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